Reversible Splenial Lesion in the Corpus Callosum on MRI after Ingestion of a Herbicide Containing Glufosinate Ammonium: A Case Report1

Abstract

Glufosinate ammonium (GLA) is a broad-spectrum herbicide used worldwide. Transient lesions involving the splenium of the corpus callosum have been described in patients with encephalitis or encephalopathy of varied etiology, but have not been reported in association with GLA poisoning. We describe a patient who had attempted suicide by ingesting GLA-containing herbicide, with a focal diffusion-restrictive lesion in the splenium of the corpus callosum on MRI, which had disappeared four weeks later with no sequalae.