Effect of nano-structured polymer surfaces on the phenotype control of preosteoblasts

Abstract

The surface nano-structure of polymer matrices is one of the important parameters for controlling cell phenotype and function in tissue engineering. Nano-structured polymer surfaces were produced via self-assembly of polystyren-b-poly(ethylene oxide)/dodecylbenzensulfonic acid complex systems. Polystyrene domain size and center-to-center distance between the domains under 100 nm strongly influenced the adhesion, proliferation, and differentiation of presteoblasts cultured on the nano-polymer surfaces, irrespective of the same total domain area.