Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-03-15T06:09:04Z | - |
dc.date.available | 2018-03-15T06:09:04Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | Immunological Investigations, Vol. 43, Issue 2, p97-112 | en_US |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.uri | http://www.tandfonline.com/doi/full/10.3109/08820139.2013.837917 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47187 | - |
dc.description.abstract | Objective: The aim of this study is to determine whether tumor necrosis factor receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in different populations. Methods: We conducted a meta-analysis of associations between the TRAF1-C5 polymorphisms and RA susceptibility. Results: A total of 24 comparative studies were included in this meta-analysis, including 22,682 patients with RA and 23,493 controls. The meta-analysis showed an association between the second allele of rs10818488 and RA in Europeans, but not in Asians (OR 1.229, 95% CI 1.094-1.381, p = 0.001; OR 1.060, 95% CI 0.930-1.335, p = 0.092). The meta-analysis also indicated an association between the second allele of rs3761847 and RA in Europeans, but not in Asians (OR 1.156, 95% CI 1.006-1.327, p = 0.041; OR 1.049, 95% CI 0.952-1.156, p = 0.333). The meta-analysis revealed an association between the second allele of the rs2900180 and rs10760130 polymorphisms and RA risk in Europeans (OR 1.224, 95% CI 1.065-1.405, p = 0.004; OR 1.072, 95% CI 1.002-1.147, p = 0.042). Conclusions: This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Healthcare Technology R&D Project, Korean Ministry of Health and Welfare (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor and Francis Online | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | polymorphism | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | TRAF1-C5 | en_US |
dc.title | Associations between TRAF1-C5 Gene Polymorphisms and Rheumatoid Arthritis: A Meta-Analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 43 | - |
dc.identifier.doi | 10.3109/08820139.2013.837917 | - |
dc.relation.page | 97-112 | - |
dc.relation.journal | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.contributor.googleauthor | Song, Gwan Gyu | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Kim, Jae-Hoon | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.relation.code | 2014030971 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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