Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용순 | - |
dc.date.accessioned | 2018-03-15T04:55:06Z | - |
dc.date.available | 2018-03-15T04:55:06Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | Nutrition Research, 2012, 32(7), P.495-502 | en_US |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0271531712001224?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47071 | - |
dc.description.abstract | Vitamin D deficiency, low levels of fetuin-A, and fibroblast growth factor 23 (FGF-23) are related to vascular calcification, which is associated with cardiovascular disease. We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. In a randomized, open-label, controlled study, a total of 47 patients treated with dialysis for at least 1 year were randomized to treatment for 6 months with omega-3 FAs (Omacor, 3 g/d; Pronova, Sandefjord, Norway) or a control group. Levels of fetuin-A and FGF-23 were measured by enzyme-linked immunoassay, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured by radioimmunoassay. The mean age of the enrolled patients was 57.4 ± 10.4 years, and mean dialysis duration was 46.5 ± 28.1 months. Twenty-seven hemodialysis patients and 16 peritoneal dialysis patients finished this trial. After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Levels of calcium, phosphorous, parathyroid hormone, 25-hydroxyvitamin D, FGF-23, and lipid profiles were not significantly changed in the omega-3 FA?supplemented group after 6 months compared with baseline. The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were significantly increased, and oleic acid content was significantly decreased in the omega-3 FA?supplemented group after 6 months compared with baseline. Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients. | en_US |
dc.description.sponsorship | This work was supported, in part, by grant Baxter 2010 from the Korean Society of Nephrology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | 1,25-dihydroxyvitamin D | en_US |
dc.subject | Dialysis | en_US |
dc.subject | Fetuin-A | en_US |
dc.subject | Fibroblast growth factor 23 | en_US |
dc.subject | Omega-3 fatty acid | en_US |
dc.subject | Human | en_US |
dc.title | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1016/j.nutres.2012.06.005 | - |
dc.relation.page | 495-502 | - |
dc.relation.journal | NUTRITION RESEARCH | - |
dc.contributor.googleauthor | An, Won-Suk | - |
dc.contributor.googleauthor | Lee, Su-Mi | - |
dc.contributor.googleauthor | Son, Young-Ki | - |
dc.contributor.googleauthor | Kim, Seong-Eun | - |
dc.contributor.googleauthor | Kim, Ki-Hyun | - |
dc.contributor.googleauthor | Han, Jin-Yeong | - |
dc.contributor.googleauthor | Bae, Hae-Rahn | - |
dc.contributor.googleauthor | Rha, Seo-Hee | - |
dc.contributor.googleauthor | Park, Yong-Soon | - |
dc.relation.code | 2012207215 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | yongsoon | - |
dc.identifier.researcherID | 7405373869 | - |
dc.identifier.orcid | 0000-0001-5110-5716 | - |
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