Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정목 | - |
dc.date.accessioned | 2018-03-15T04:08:07Z | - |
dc.date.available | 2018-03-15T04:08:07Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | Scandinavian Journal of Gastroenterology, 2014, 49(8), p917-924 | en_US |
dc.identifier.issn | 1502-7708 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/00365521.2014.896409 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/47031 | - |
dc.description.abstract | Objective. The eradication rate of 10-day sequential therapy for Helicobacter pylori (H. pylori) infection was not satisfactory in Korea, probably due to antibiotic resistance. To compare the treatment efficacy of 15-day and 10-day sequential therapy of conventional 7-day proton pump inhibitor (PPI) triple therapy for the treatment of H. pylori infection. Methods. A total of 332 patients with H. pylori infection were randomly assigned to receive either 7-day PPI triple therapy, 10-day sequential therapy or 15-day sequential therapy. Eradication rate, drug compliance, and adverse events were compared among the three regimens. Results. The eradication rates by intention-to-treat analysis were 64.3% (95% CI: 55.5-73.2; 74 of 115 patients), 72.1% (95% CI: 63.6-80.5; 80 of 111 patients), and 80.2% (95% CI: 72.5-87.9; 85 of 106 patients) in the 7-day PPI triple, 10-day and 15-day sequential therapy groups, respectively (p = 0.032). The eradication rates by per-protocol analysis were 68.5% (95% CI: 59.6-77.4; 74 of 108 patients), 78.4% (95% CI: 70.3-86.5; 80 of 102 patients), and 89.5% (95% CI: 83.2-95.8; 85 of 95 patients) in the 7-day PPI triple, 10-day and 15-day sequential therapy groups, respectively (p = 0.001). There were no statistically significant differences between the three eradication therapy groups in regard to drug compliance and adverse events. Conclusion. The 15-day sequential therapy demonstrated improved eradication efficacy compared with 7-day PPI triple and 10-day sequential therapy in Korea. | en_US |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation of Korea funded by the Korean Government (NRF-2012R1A1B5002680). | en_US |
dc.language.iso | en | en_US |
dc.publisher | TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | en_US |
dc.subject | 15-day sequential | en_US |
dc.subject | eradication | en_US |
dc.subject | Helicobacter pylori | en_US |
dc.subject | resistance | en_US |
dc.title | A comparison between 15-day sequential, 10-day sequential and proton pump inhibitor-based triple therapy for Helicobacter pylori infection in Korea | en_US |
dc.type | Article | en_US |
dc.relation.volume | 49 | - |
dc.identifier.doi | 10.3109/00365521.2014.896409 | - |
dc.relation.page | 917-924 | - |
dc.relation.journal | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.contributor.googleauthor | Kim, Jae-Yeon | - |
dc.contributor.googleauthor | Lee, Dong-Ho | - |
dc.contributor.googleauthor | Jung, Hyun-Chae | - |
dc.contributor.googleauthor | Nam, Ryoung-Hee | - |
dc.contributor.googleauthor | Kim, Jung-Mogg | - |
dc.contributor.googleauthor | Kim, Na-Young | - |
dc.contributor.googleauthor | Lee, Ju-Yup | - |
dc.contributor.googleauthor | Lee, Jung-Won | - |
dc.relation.code | 2014039148 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jungmogg | - |
dc.identifier.researcherID | 34771324000 | - |
dc.identifier.orcid | 0000-0002-6506-7519 | - |
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