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dc.contributor.author정승준-
dc.date.accessioned2018-03-15T01:43:00Z-
dc.date.available2018-03-15T01:43:00Z-
dc.date.issued2014-08-
dc.identifier.citationMolecular Brain, 2014, 7, p1-10en_US
dc.identifier.issn1756-6606-
dc.identifier.urihttps://molecularbrain.biomedcentral.com/articles/10.1186/s13041-014-0059-9-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/46961-
dc.description.abstractBackground: Recent studies have indicated that Toll-like receptor 4 (TLR4), a pathogen-recognition receptor that triggers inflammatory signals in innate immune cells, is also expressed on sensory neurons, implicating its putative role in sensory signal transmission. However, the possible function of sensory neuron TLR4 has not yet been formally addressed. In this regard, we investigated the role of TLR4 in itch signal transmission.Results: TLR4 was expressed on a subpopulation of dorsal root ganglia (DRG) sensory neurons that express TRPV1. In TLR4-knockout mice, histamine-induced itch responses were compromised while TLR4 activation by LPS did not directly elicit an itch response. Histamine-induced intracellular calcium signals and inward currents were comparably reduced in TLR4-deficient sensory neurons. Reduced histamine sensitivity in the TLR4-deficient neurons was accompanied by a decrease in TRPV1 activity. Heterologous expression experiments in HEK293T cells indicated that TLR4 expression enhanced capsaicin-induced intracellular calcium signals and inward currents.Conclusions: Our data show that TLR4 on sensory neurons enhances histamine-induced itch signal transduction by potentiating TRPV1 activity. The results suggest that TLR4 could be a novel target for the treatment of enhanced itch sensation.en_US
dc.description.sponsorshipThe work was supported by the National Research Foundation of Korea, funded by the Ministry of Science, ICT, and Future Planning (2013R1A1A2074231), Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherBIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLANDen_US
dc.subjectToll-like receptoren_US
dc.subjectItchen_US
dc.subjectSensory neuronsen_US
dc.titleTLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activityen_US
dc.typeArticleen_US
dc.relation.volume7-
dc.identifier.doi10.1186/s13041-014-0059-9-
dc.relation.page1-2-
dc.relation.journalMOLECULAR BRAIN-
dc.contributor.googleauthorMin, Hyun-Jung-
dc.contributor.googleauthorLee, Hyun-Kyoung-
dc.contributor.googleauthorLim, Hyoung-Sub-
dc.contributor.googleauthorJang, Yong-Ho-
dc.contributor.googleauthorChung, Sung-Jun-
dc.contributor.googleauthorLee, C. Justin-
dc.contributor.googleauthorLee, Sung-Joong-
dc.relation.code2014036190-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
dc.identifier.researcherID56349646500-


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