Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최호진 | - |
dc.date.accessioned | 2018-03-15T01:33:30Z | - |
dc.date.available | 2018-03-15T01:33:30Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | MOLECULAR BIOLOGY REPORTS, 2012, 39(4), P.3755-3765 | en_US |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs11033-011-1152-0 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46944 | - |
dc.description.abstract | The roles of mitochondrial glutaredoxin (Grx2a) under serum deprivation were assessed using the human stable HepG2 cell lines overexpressing or down-regulating Grx2a. The Grx2a-overexpressing stable cells displayed enhanced proliferation, decreased reactive oxygen species (ROS) and caspase-3 activity levels, and increased total GSH level, compared to the vector control cells. These characteristics of the overexpressing stable cells were reversed by down-regulating Grx2a in the same cell line. In the limited serum conditions, the Grx2a-overexpressing stable pcDNA3.0/HA-Grx2a cells exhibited higher cellular viabilities and total GSH level, and showed much lower enhancement in ROS and caspase-3 activity levels than the vector control pcDNA3.0/HA cells. However, the Grx2a-down-regulating stable cells gave rise to diminished cellular viabilities and further decreased total GSH level, and contained significantly higher ROS and caspase-3 activity levels, under serum deprivation than the vector control cells. These results suggest that Grx2a plays proliferative and anti-apoptotic roles under serum deprivation. | en_US |
dc.description.sponsorship | National Research Foundation of Korea (NRF) Ministry of Education, Science and Technology | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Glutaredoxin | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.subject | Serum deprivation | en_US |
dc.subject | Apoptosis | en_US |
dc.title | Glutaredoxin 2a, a mitochondrial isoform, plays a protective role in a human cell line under serum deprivation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s11033-011-1152-0 | - |
dc.relation.journal | MOLECULAR BIOLOGY REPORTS | - |
dc.contributor.googleauthor | Kim, Su-Jung | - |
dc.contributor.googleauthor | Jung, Hyun-Joo | - |
dc.contributor.googleauthor | Choi, Hojin | - |
dc.contributor.googleauthor | Lim, Chang-Jin | - |
dc.relation.code | 2012206806 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chj | - |
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