Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-03-15T01:27:49Z | - |
dc.date.available | 2018-03-15T01:27:49Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2014, 449(4), P.471-476 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006291X14009024?via%3Dihub | - |
dc.description.abstract | We previously identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistant biomarker in p53 wild-type A549 cells and found that p53-dependent induction of the PUMA pathway was a critical event in regulating the radioresistant phenotype. Here, we found that HRP-3 knockdown regulates the radioresistance of p53- H1299 cells through a distinctly different molecular mechanism. HRP-3 depletion was sufficient to cause apoptosis of H1299 cells by generating substantial levels of reactive oxygen species (ROS) through inhibition of the Nrf2/HO-1 antioxidant pathway. Subsequent, ROS-dependent and p53-independent NF-kappa B activation stimulated expression of c-Myc and Noxa proteins, thereby inducing the apoptotic machinery. Our results thus extend the range of targets for the development of new drugs to treat both p53 wild-type or p53- radioresistant lung cancer cells. (C) 2014 The Authors. Published by Elsevier Inc. | en_US |
dc.description.sponsorship | This work was supported by the Nuclear Research & Development Program of the National Research Foundation grant of Korean (2012M2A2A7012007). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science INC | en_US |
dc.subject | H1299 cells | en_US |
dc.subject | HRP-3 | en_US |
dc.subject | Myc/Noxa signaling | en_US |
dc.subject | NF-kappa B | en_US |
dc.subject | ROS | en_US |
dc.title | Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-kappa B activation | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 449 | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.05.039 | - |
dc.relation.page | 471-476 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Yun, Hong Shik | - |
dc.contributor.googleauthor | Baek, Jeong-Hwa | - |
dc.contributor.googleauthor | Yim, Ji-Hye | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Lee, Chang-Woo | - |
dc.contributor.googleauthor | Song, Jie-Young | - |
dc.contributor.googleauthor | Um, Hong-Duck | - |
dc.contributor.googleauthor | Park, Jong Kuk | - |
dc.contributor.googleauthor | Park, In-Chul | - |
dc.contributor.googleauthor | Hwang, Sang-Gu | - |
dc.relation.code | 2014026012 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.