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A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases

Title
A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases
Author
이창호
Keywords
antioxidant effect; cardiovascular diseases; lipid profile; myocardial protection; vasomotor tone
Issue Date
2014-07
Publisher
Korean SOC Ginseng
Citation
Journal of Korean SOC Ginseng, 2014, P.161-166
Abstract
Ginseng is widely used for its promising healing and restorative properties as well as for its possible tonic effect in traditional medicine. Nowadays, many studies focus on purified individual ginsenoside, an important constituent in ginseng, and study its specific mechanism of action instead of whole-plant extracts on cardiovascular diseases (CVDs). Of the various ginsenosides, purified ginsenosides such as Rb1, Rg1, Rg3, Rh1, Re, and Rd are the most frequently studied. Although there are many reports on the molecular mechanisms and medical applications of ginsenosides in the treatment of CVDs, many concerns exist in their application. This review discusses current works on the countless pharmacological functions and the potential benefits of ginseng in the area of CVDs. Results: Both in vitro and in vivo results indicate that ginseng has potentially positive effects on heart disease through its various properties including antioxidation, reduced platelet adhesion, vasomotor regulation, improving lipid profiles, and influencing various ion channels. To date, approximately 40 ginsenosides have been identified, and each has a different mechanism of action owing to the differences in chemical structure. This review aims to present comprehensive information on the traditional uses, phytochemistry, and pharmacology of ginseng, especially in the control of hypertension and cardiovascular function. In addition, the review also provides an insight into the opportunities for future research and development on the biological activities of ginseng. Copyright (C) 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.
URI
http://www.ginsengres.com/article/S1226-8453(14)00049-9/fulltexthttp://hdl.handle.net/20.500.11754/46858
ISSN
1226-8453; 2093-4947
DOI
10.1016/j.jgr.2014.03.001
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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