Metal-Free C-H Amination for Indole Synthesis
- Title
- Metal-Free C-H Amination for Indole Synthesis
- Author
- 윤소원
- Keywords
- PALLADIUM-CATALYZED REACTIONS; HYPERVALENT IODINE REAGENTS; 2,3-DICHLORO-5,6-DICYANO-1,4-BENZOQUINONE DDQ; 4-SUBSTITUTED INDOLES; HIGHLY EFFICIENT; MILD CONDITIONS; STYRYL AZIDES; PHENONIUM ION; OXIDATION; FUNCTIONALIZATION
- Issue Date
- 2014-07
- Publisher
- Amer Chemical SOC
- Citation
- Organic Letters, Jul 2014, 16(14), P.3720-3723,
- Abstract
- An effective metal-free C-H amination of N-Ts-2-alkenylanilines by using DDQ as an oxidant has been developed to afford a diverse range of substituted indoles. This protocol is operationally simple and robust, obviates the need of expensive transition-metal catalysts, and offers a broad substrate scope. A mechanism involving a radical cation generated by SET and a migratorial process via a phenonium ion intermediate is proposed.
- URI
- https://pubs.acs.org/doi/10.1021/ol5015398
- ISSN
- 1523-7060
- DOI
- 10.1021/ol5015398
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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