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Impact of agglomeration on the bioaccumulation of sub-100 nm sized TiO2

Title
Impact of agglomeration on the bioaccumulation of sub-100 nm sized TiO2
Author
윤태현
Keywords
Nanoparticle toxicity; Dose-response; Agglomeration; Effective dose; Bioaccumulation; IN-VITRO; NANOPARTICLE TOXICITY; CYTOTOXICITY ASSAYS; CARBON NANOTUBES; DAPHNIA-MAGNA; DISPERSION; MEDIA; ACCUMULATION; DOSIMETRY; EXPOSURE
Issue Date
2014-01
Publisher
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Citation
Colloids and Surfaces B: Biointerfaces, Vol 116, 1 April 2014, Pages 277-283
Abstract
To improve our understanding on the impact of extrinsic properties of NPs on their bioaccumulation and toxicity, we have investigated the bioaccumulation of sub 100 nm sized P25 TiO2 nanoparticles (NPs) by Daphnia magna (D. magna) in toxicity testing media. Based on our quantitative ICP-MS measurements as well as spectromicroscopic observations, we found that the bioaccumulation by D. magna were strongly influenced by the extrinsic properties of NPs as well as the biological uptake characteristics of D. magna. New sets of effective dosimetry parameters well correlated with the amount of NPs bioaccumulated within D. magna were also proposed. Based on these findings, we suggested that the extrinsic physicochemical properties of NPs (e.g., interfacial and colloidal properties of NPs) and biological characteristics for NPs (e.g., uptake cutoff sizes of testing organisms) should be considered and included when developing alternative dosimetry of NPs. (C) 2014 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0927776513008023http://hdl.handle.net/20.500.11754/46779
ISSN
0927-7765
DOI
10.1016/j.colsurfb.2013.12.047
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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