Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population
- Title
- Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population
- Author
- 이창화
- Keywords
- C-REACTIVE PROTEIN; METABOLIC SYNDROME; RISK-FACTORS; KOREAN POPULATION; DISEASE; IRON; NEURODEGENERATION; PATHOGENESIS; HEALTH; CELLS
- Issue Date
- 2016-04
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v. 11, NO 4, Page. 1-11
- Abstract
- Ferritin is considered to be a marker of the body's iron stores and has a potential relationship with the systemic manifestations of inflammatory reactions. Data on the association between increased levels of serum ferritin and ocular problems are limited, particularly in relation to age-related macular degeneration (AMD). Serum ferritin levels, as a possible clinical parameter for predicting AMD, were analyzed in anthropometric, biochemical, and ophthalmologic data from a nation-wide, population-based, case-control study (KNHNES IV and V). All native Koreans aged ˃= 20 years and who had no medical illness were eligible to participate. Among them, 2.9% had AMD, and its prevalence was found to increase in the higher ferritin quintile groups (P-trend ˂ 0.0001). In multiple linear regression analysis, serum ferritin level was closely related to conventional risk factors for AMD. Comparison of early AMD with a control group showed that serum ferritin levels were closely associated with AMD (OR = 1.004, 95% CI = 1.002-1.006), and further adjustment for age, gender, serum iron, and kidney function did not reduce this association (OR = 1.003, 95% CI = 1.001-1.006). Furthermore, the relationship between ferritin quintile and early AMD was dose-dependent. Thus, an increased level of serum ferritin in a healthy person may be a useful indicator of neurodegenerative change in the macula. A large population-based prospective clinical study is needed to confirm these findings.
- URI
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153624http://hdl.handle.net/20.500.11754/46735
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0153624
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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