Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전재범 | - |
dc.date.accessioned | 2018-03-14T05:30:42Z | - |
dc.date.available | 2018-03-14T05:30:42Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | Journal of Korean medical science, 2014, 29(8), p1090-1093 | en_US |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2014.29.8.1090 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46626 | - |
dc.description.abstract | We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNF alpha). The study participants (n = 127) had a negative IGRA screening before receiving anti-TNF alpha and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNF alpha, including type and treatment duration. The median duration of anti-TNF alpha was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P = 0.12). IGRA conversion was observed in AS patients receiving anti-TNF alpha in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNF alpha. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2013-G). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES, 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA | en_US |
dc.subject | Ankylosing Spondylitis | en_US |
dc.subject | Interferon-Gamma Release Assay | en_US |
dc.subject | Anti-Tumor Necrosis Factor | en_US |
dc.subject | Latent Tuberculosis Infection | en_US |
dc.title | Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 29 | - |
dc.identifier.doi | 10.3346/jkms.2014.29.8.1090 | - |
dc.relation.page | 1090-1093 | - |
dc.relation.journal | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.contributor.googleauthor | Son, Chang-Nam | - |
dc.contributor.googleauthor | Jun, Jae-Bum | - |
dc.contributor.googleauthor | Kim, Jong-Heon | - |
dc.contributor.googleauthor | Sung, Il-Hoon | - |
dc.contributor.googleauthor | Yoo, Dae-Hyun | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.relation.code | 2014033608 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | junjb | - |
dc.identifier.researcherID | 6701832754 | - |
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