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Exercise Training suppresses vascular fibrosis in aging obesity induced rats

Title
Exercise Training suppresses vascular fibrosis in aging obesity induced rats
Author
이진
Keywords
Exercise training; vascular fibrosis
Issue Date
2014-06
Publisher
한국운동영양학회(Korean Academy Society of Exercise Nutrition)
Citation
Journal of Exercise Nutrition & Biochemistry, 권: 18, 호: 2, 페이지: 175-180
Abstract
Shin Young Kim and Jin Lee. Exercise Training suppresses vascular fibrosis in aging obesity induced rats. JENB., Vol. 18, No.2, pp.175-180, 2014 [Purpose] The aim of this study was to investigate the effects of exercise training (ET) on vascular fibrosisin aging model rats with diet-induced obesity. [Methods] Twenty-four male Sprague-Dawley rats were divided into 3 groups:Aging control (A-C), A-C with high fat diet (AHF), AHF with ET (AHF + ET). Aging was induced by D-galactose (D-gal) andobesity was induced by HFD (60% fat) for 9 weeks. The experimental rats performed swimming (60 min/day, 5 days/week) for8 weeks. All rat aorta samples were harvested for RT-PCR and morphologic analyses. [Results] The exercise training significantlydecreased levels of AT-1, TGF-SS and Coll-1 gene expression compared to AHF group. The AHF + ET group showed a reducedcollagen accumulation in the aorta media compared to AHF group. [Conclusion] These results suggest that ET could protect theaging obesity aorta against down-regulation of fibrotic factors (AT-1, TGF-SS and Coll-1 gene) and fibrosis by inhibition of collagenaccumulation in the aorta media. [Keyword] Exercise training, vascular fibrosis
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3253663http://hdl.handle.net/20.500.11754/46612
ISSN
2233-6834
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
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