Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김교상 | - |
dc.date.accessioned | 2018-03-14T01:45:38Z | - |
dc.date.available | 2018-03-14T01:45:38Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | Korean J Anesthesiol, 2014, 67(1), P.26-31 | en_US |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.issn | 2005-7563 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4097/kjae.2014.67.1.26 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46450 | - |
dc.description.abstract | BackgroundThe aim of this randomized, double-blind, placebo-controlled study was to evaluate dose effects of ephedrine pretreatment on the onset time and intubating conditions after cisatracurium administration.MethodsA total of 140 adult patients were randomized into 4 groups to receive either 30 μg/kg ephedrine (Group 30, n = 35), 70 μg/kg ephedrine (Group 70, n = 35), 110 μg/kg ephedrine (Group 110, n = 35), 3 ml normal saline (Group C, n = 35) as pretreatment given 30 s before anesthetic induction. Neuromuscular block was achieved with 0.15 mg/kg cisatracurium, evaluated accelomyographically with train-of-four stimulation. An anesthesiologist blinded to patient grouping assessed the intubating conditions 1.5 min after cisatracurium administration.ResultsAn onset time of 70 s was obtained in the ephedrine groups (Group 30: 155.4 ± 44.7 s, Group 70: 152.6 ± 40.3 s, Group 110: 151.2 ± 51.6 s) compared to Group C (224.6 ± 56.9 s) after 0.15 mg/kg of cisatracurium (P < 0.001). Ephedrine doses of either 70 or 110 μg/kg for pretreatment significantly improved intubating conditions (P < 0.05). Systolic and diastolic blood pressure and heart rate at 1 min after tracheal intubation were significantly increased than other times in all groups (P < 0.001), with no differences among the groups. However, 5 patients in Group 110 experienced marked hypertension (systolic/diastolic blood pressure: > 200/100 mmHg) 1 min after tracheal intubation with no patients in other groups.ConclusionsWe conclude that pre-treatment with ephedrine 70 μg/kg improved intubating conditions 1.5 min after cisatracurium administration and facilitated the onset of neuromuscular block (70 s) without adverse hemodynamic effects. | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | Cisatracurium | en_US |
dc.subject | Ephedrine | en_US |
dc.subject | Hemodynamics | en_US |
dc.subject | Intubation | en_US |
dc.title | The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 67 | - |
dc.identifier.doi | 10.4097/kjae.2014.67.1.26 | - |
dc.relation.page | 26-31 | - |
dc.relation.journal | Korean Journal of Anesthesiology | - |
dc.contributor.googleauthor | Cha, Dong Guk | - |
dc.contributor.googleauthor | Kwon, Hye Mee | - |
dc.contributor.googleauthor | Jeong, Ji Seon | - |
dc.contributor.googleauthor | Kim, Kyo Sang | - |
dc.relation.code | 2014015879 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimks | - |
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