Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features
- Title
- Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features
- Author
- 박용욱
- Keywords
- Acquired cystic disease; Renal cell carcinoma; c-met; Target therapy
- Issue Date
- 2013-12
- Publisher
- Springer Science + Business Media
- Citation
- Medical Molecular Morphology, Vol.46, No.4 [2013], p225?232
- Abstract
- Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) with unique morphologic features found exclusively in the background of end-stage renal disease. We analyzed the clinicopathologic features and immumoreactive profiles of 12 cases of ACD-RCC to further characterize this recently recognized entity. Review of histologic slides was performed in conjunction with immunohistochemical staining directed to the contemporary diagnostic antibodies and the putative target therapy-related markers. Histologically, the tumors showed characteristic inter-or intracellular microlumens and eosinophilic tumor cells. Intratumoral hemosiderin deposition and degenerating foamy tumor cells were consistent findings which were not previously described. Immunohistochemically, all the tumors were positive for alpha-methylacyl-CoA-racemase, CD10, pan-cytokeratin, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and c-met, while negative for carbonic anhydrase-9, CD57, CD68, c-kit, pax-2, platelet-derived growth factor receptor (PDGFR)-α or vascular endothelial growth factor receptor (VEGFR)-2. Heterogenous staining was found for CK7 and kidney-specific cadherin. Positive reaction to c-met suggests its utility as a plausible therapeutic target in ACD-RCC. Thus, we present the unique morphologic and immunopathologic features of ACD-RCC, which may be helpful in both diagnostic and therapeutic aspects.
- URI
- http://link.springer.com/article/10.1007/s00795-013-0028-xhttp://hdl.handle.net/20.500.11754/46369
- ISSN
- 1860-1480
- DOI
- 10.1007/s00795-013-0028-x
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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