Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승훈 | - |
dc.date.accessioned | 2018-03-13T06:38:04Z | - |
dc.date.available | 2018-03-13T06:38:04Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | Nature genetics, 2013, 45(7), p.730 - 738 | en_US |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://www.nature.com/articles/ng.2667 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46073 | - |
dc.description.abstract | Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis?associated haplotypes at 11 loci. Two ankylosing spondylitis?associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression. | en_US |
dc.description.sponsorship | The Wellcome Trust Case Control Consortium 2 project is funded by the Wellcome Trust (083948/Z/07/Z). We acknowledge use of the British 1958 Birth Cohort DNA collection, funded by the Medical Research Council (G0000934) and the Wellcome Trust (068545/Z/02), and of the UK National Blood Service controls, funded by the Wellcome Trust | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | GENOME-WIDE ASSOCIATION | en_US |
dc.subject | DISEASE SUSCEPTIBILITY LOCI | en_US |
dc.subject | HLA CLASS-I; | en_US |
dc.title | Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci | en_US |
dc.type | Article | en_US |
dc.relation.volume | 45 | - |
dc.identifier.doi | 10.1038/ng.2667 | - |
dc.relation.page | 730-740 | - |
dc.relation.journal | NATURE GENETICS | - |
dc.contributor.googleauthor | Cortes, Adrian | - |
dc.contributor.googleauthor | Hadler, Johanna | - |
dc.contributor.googleauthor | Pointon, Jenny | - |
dc.contributor.googleauthor | Robinson, Philip | - |
dc.contributor.googleauthor | Karaderi, Tugce | - |
dc.contributor.googleauthor | Leo, Paul | - |
dc.contributor.googleauthor | Cremin, Katie | - |
dc.contributor.googleauthor | Pryce, Karena | - |
dc.contributor.googleauthor | Harris, Jessica | - |
dc.contributor.googleauthor | Lee, Seunghun | - |
dc.relation.code | 2013011397 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | radsh | - |
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