Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용수 | - |
dc.date.accessioned | 2018-03-13T05:39:49Z | - |
dc.date.available | 2018-03-13T05:39:49Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | The Korean journal of internal medicine : KJIM , 2013, 28(3), pp.306 - 313 | en_US |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | http://kjim.org/journal/view.php?doi=10.3904/kjim.2013.28.3.306 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45977 | - |
dc.description.abstract | Background/AimsThe aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM).MethodsA cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose ≥ 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281).ResultsThe GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin sensitivity check index, homeostasis model assessment for estimation of index β-cell secretion (HOMA-B), first and second phase insulin secretion, and insulin secretion-sensitivity index (ISSI) than the NGT group (p ≤ 0.001 for all). Moreover, the GIGT group had lower ISOGTT, HOMA-B, first and second phase insulin secretion, and ISSI than the NGT group (p < 0.001 for all). Among the GIGT subjects, the 1-hour plasma glucose abnormal levels group showed significantly greater weight gain during pregnancy and higher values in the 50-g OGCT than the other two groups. Moreover, the 1-hour and 2-hour abnormal levels groups had poorer insulin secretion status than the 3-hour abnormal levels group.ConclusionsKorean women with GDM show impairments of both insulin secretion and insulin sensitivity. In addition, GIGT is associated with both β-cell dysfunction and insulin resistance. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ASSOCIATION OF INTERNAL MEDICINE | en_US |
dc.subject | Gestational diabetes mellitus | en_US |
dc.subject | Gestational impaired glucose tolerance | en_US |
dc.subject | Insulin secretion | en_US |
dc.subject | Insulin resistance | en_US |
dc.title | Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.3904/kjim.2013.28.3.306 | - |
dc.relation.page | 306-313 | - |
dc.relation.journal | Korean Journal of Internal Medicine | - |
dc.contributor.googleauthor | Yang, S.J. | - |
dc.contributor.googleauthor | Kim, T.N. | - |
dc.contributor.googleauthor | Baik, S.H | - |
dc.contributor.googleauthor | Kim, T.S. | - |
dc.contributor.googleauthor | Lee, K.W | - |
dc.contributor.googleauthor | Nam, M | - |
dc.contributor.googleauthor | Park, Y.S. | - |
dc.contributor.googleauthor | Woo, J.-T | - |
dc.contributor.googleauthor | Kim, Y.S. | - |
dc.contributor.googleauthor | Kim, S.-H. | - |
dc.relation.code | 2013042463 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkys | - |
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