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Fabrication of superabsorbent ultrathin nanofibers using mesoporous materials for antimicrobial drug-delivery applications

Title
Fabrication of superabsorbent ultrathin nanofibers using mesoporous materials for antimicrobial drug-delivery applications
Author
임승순
Keywords
biomedical polymer; controlled release; drug delivery; microbial materials; TS-1 zeolite; ultrathin nanofiber
Issue Date
2013-06
Publisher
THE POLYMER SOCIETY OF KOREA
Citation
Macromolecular Research, November , 2013, 21(11), P.1281-1288
Abstract
The goal of this study was to prepare functionalized, ultrathin nanofibers using mesoporous materials (TS-1 zeolite) with maximum capability to both absorb drug and control drug release (these fibers are herein referred to as PZ-01); a second goal was to prepare nanofibers that exhibit biodegradability after drug release. Under optimal conditions, the characteristic of TS-1 zeolite enabled the preparation of ultrathin nanofibers with diameters below 100 nm, or one-twentieth the size of homo-poly(butylene succinate) (PBS) fibers. In addition, PZ-01 nanofibers exhibited high drug loading capacity compared to homo-PBS fibers. This result was attributable to the large surface area of ultrathin nanofibers and to the strong ionic interaction between hydrophilic drugs and the metal ions of TS-1 zeolite. In vitro cytostatic assay indicated that prepared PZ-01 has cytostatic action toward both Gram-positive and Gram-negative bacteria. The excellent drug wetting behavior of PZ-01 led to longer drug-release times. After drugrelease tests, antibacterial tests confirmed that homo-PBS fibers had diminished antibiotic activity regardless of the type of bacteria, whereas the antibacterial activity of tested PZ-01 was highly efficient against both Gram-positive and Gram-negative bacteria. In the cell viability test, PZ-01 exhibited a greater decrease in cytotoxicity and an increase in cell viability compared with the homo-PBS nanofiber. Based on this research, we anticipate that these materials will be promising candidates for biomedical applications such as biofilters for microbes, wound dressings, and drug-delivery products
URI
https://link.springer.com/article/10.1007/s13233-013-1178-3http://hdl.handle.net/20.500.11754/45921
ISSN
1598-5032
DOI
10.1007/s13233-013-1178-3
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ORGANIC AND NANO ENGINEERING(유기나노공학과) > Articles
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