Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임동우 | - |
dc.date.accessioned | 2018-03-13T04:41:19Z | - |
dc.date.available | 2018-03-13T04:41:19Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, 권: 9, 페이지: 33-49 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-peer-reviewed-article-IJN | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45877 | - |
dc.description.abstract | Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with sideby- side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea, and was funded by the Ministry of Education, Science and Technology, Korea (2010-0013284, 2012R1A1A2043792, 2012-0009838, and R11-2008-044-01002-0), the Ministry of Science, Information and Communication Technology (ICT) and Future Planning, Korea (2013R1A2A2A04016796), and by the Agency for Defense Development through the Chemical and Biological Research Center. | en_US |
dc.language.iso | en | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND | en_US |
dc.subject | stimuli responsiveness | en_US |
dc.subject | anisotropy | en_US |
dc.subject | nanofibers | en_US |
dc.subject | actuation | en_US |
dc.subject | drug delivery | en_US |
dc.subject | tissue engineering | en_US |
dc.title | Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.2147/IJN.S51842 | - |
dc.relation.page | 33-49 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Jalani, Ghulam | - |
dc.contributor.googleauthor | Jung, Chan Woo | - |
dc.contributor.googleauthor | Lee, Jae Sang | - |
dc.contributor.googleauthor | Lim, Dong Woo | - |
dc.relation.code | 2014031644 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | dlim | - |
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