Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승현 | - |
dc.date.accessioned | 2018-03-12T08:32:57Z | - |
dc.date.available | 2018-03-12T08:32:57Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 권: 23, 호: 13, 페이지: 3983-3987 | en_US |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X13004472?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45569 | - |
dc.description.abstract | New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 mu M). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration. (c) 2013 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by a Grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A091049-1222-0000300). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Glycogen synthase kinase-3 | en_US |
dc.subject | GSK-3 inhibitor | en_US |
dc.subject | 8-Amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives | en_US |
dc.title | Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors | en_US |
dc.type | Article | en_US |
dc.relation.no | 13 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.03.119 | - |
dc.relation.page | 3983-3987 | - |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.contributor.googleauthor | Chun, Kwangwoo | - |
dc.contributor.googleauthor | Park, Ji-Seon | - |
dc.contributor.googleauthor | Lee, Han-Chang | - |
dc.contributor.googleauthor | Kim, Young-Ha | - |
dc.contributor.googleauthor | Ye, In-Hea | - |
dc.contributor.googleauthor | Kim, Kang-Jeon | - |
dc.contributor.googleauthor | Ku, Il-Whea | - |
dc.contributor.googleauthor | Noh, Min-Young | - |
dc.contributor.googleauthor | Cho, Goang-Won | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.relation.code | 2013009161 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimsh1 | - |
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