Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전하정 | - |
dc.date.accessioned | 2018-03-12T04:27:21Z | - |
dc.date.available | 2018-03-12T04:27:21Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 34, 7, 2006-2010 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2013_v34n7_2006 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45280 | - |
dc.description.abstract | Leukocyte common antigen-related phosphatase (LAP.) has been considered a promising target for the development of therapeutics for neurological diseases. Here, we report the first example for a successful application of the structure-based virtual screening to identify the novel small-molecule LAP. inhibitors. Five of these inhibitors revealed micromolar inhibitory activities with the associated IC50 values ranging from 2 to 6 mu M. Because the newly identified inhibitors were also screened for having desirable physicochemical properties as a drug candidate, they may serve as a starting point of the structure-activity relationship study to optimize the medical efficacy. Structural features relevant to the stabilization of the new inhibitors in the active site of LAR are discussed in detail. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN CHEMICAL SOC, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREA | en_US |
dc.subject | Virtual screening | en_US |
dc.subject | Docking | en_US |
dc.subject | LAR | en_US |
dc.subject | Inhibitor | en_US |
dc.subject | Drug design | en_US |
dc.title | Identification of Potent Leukocyte Common Antigen-Related Phosphatase Inhibitors via Structure-Based Virtual Screening | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.5012/bkcs.2013.34.7.2006 | - |
dc.relation.page | 2006-2010 | - |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.googleauthor | Park, Hwangseo | - |
dc.contributor.googleauthor | Chien, Pham Ngoc | - |
dc.contributor.googleauthor | Chun, Ha-Jung | - |
dc.contributor.googleauthor | Ryu, Seong Eon | - |
dc.relation.code | 2013009261 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | rthcchun | - |
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