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dc.contributor.author전하정-
dc.date.accessioned2018-03-12T04:27:21Z-
dc.date.available2018-03-12T04:27:21Z-
dc.date.issued2013-07-
dc.identifier.citationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, 34, 7, 2006-2010en_US
dc.identifier.issn0253-2964-
dc.identifier.urihttp://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2013_v34n7_2006-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45280-
dc.description.abstractLeukocyte common antigen-related phosphatase (LAP.) has been considered a promising target for the development of therapeutics for neurological diseases. Here, we report the first example for a successful application of the structure-based virtual screening to identify the novel small-molecule LAP. inhibitors. Five of these inhibitors revealed micromolar inhibitory activities with the associated IC50 values ranging from 2 to 6 mu M. Because the newly identified inhibitors were also screened for having desirable physicochemical properties as a drug candidate, they may serve as a starting point of the structure-activity relationship study to optimize the medical efficacy. Structural features relevant to the stabilization of the new inhibitors in the active site of LAR are discussed in detail.en_US
dc.language.isoenen_US
dc.publisherKOREAN CHEMICAL SOC, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREAen_US
dc.subjectVirtual screeningen_US
dc.subjectDockingen_US
dc.subjectLARen_US
dc.subjectInhibitoren_US
dc.subjectDrug designen_US
dc.titleIdentification of Potent Leukocyte Common Antigen-Related Phosphatase Inhibitors via Structure-Based Virtual Screeningen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume34-
dc.identifier.doi10.5012/bkcs.2013.34.7.2006-
dc.relation.page2006-2010-
dc.relation.journalBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.contributor.googleauthorPark, Hwangseo-
dc.contributor.googleauthorChien, Pham Ngoc-
dc.contributor.googleauthorChun, Ha-Jung-
dc.contributor.googleauthorRyu, Seong Eon-
dc.relation.code2013009261-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidrthcchun-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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