Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus
- Title
- Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus
- Author
- 박용수
- Keywords
- Omentin-1; Vascular stiffness; Adipokines
- Issue Date
- 2013-12
- Publisher
- Springer Science + Business Media
- Citation
- Endocrine, Vol.44, No.3 [2013], p680–687
- Abstract
- Omentin-1 is an adipokine implicated in diabetes, inflammation, and cardiovascular disease. However, no prospective studies have examined the impact of circulating omentin-1 levels on arterial stiffening in patients with type 2 diabetes mellitus. For the purpose of this study, we recruited 120 patients with type 2 diabetes mellitus and measured serum omentin-1, adiponectin, and high-sensitivity C-reactive protein levels as well as other cardiovascular risk factors. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV). An increase in the level of circulating omentin-1 over a period of 1 year was positively correlated with changes in levels of HbA1c and serum adiponectin as well as baPWV. Subjects with higher baseline serum omentin-1 levels tended to have a reduced arterial stiffness after 1 year (P for linear trend = 0.03). In the group with increased baPWV after 1 year, the magnitude of increase of circulating omentin-1 levels was significantly higher than in the group with a lower baPWV after 1 year (134.3 [16.6, 277.1] ng/mL vs. 15.9 [-67.6, 145.7] ng/mL, P < 0.01). Multiple stepwise logistic regression analysis revealed that an increase in systolic blood pressure and an increase in serum omentin-1 level were independently correlated with arterial stiffening, even after adjusting for other cardiovascular risk factors and medication history. Baseline serum omentin-1 levels can predict arterial stiffness changes occurring within a year. Furthermore, changes in serum omentin-1 levels after a year can function as independent markers of arterial stiffening in patients with type 2 diabetes mellitus.
- URI
- http://link.springer.com/article/10.1007%2Fs12020-013-9930-1http://hdl.handle.net/20.500.11754/45206
- ISSN
- 1355-008X
- DOI
- 10.1007/s12020-013-9930-1
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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