Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상헌 | - |
dc.date.accessioned | 2018-03-12T01:55:41Z | - |
dc.date.available | 2018-03-12T01:55:41Z | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | Tuberculosis, 2013, 93(2), P.270-274 | en_US |
dc.identifier.issn | 1472-9792 | - |
dc.identifier.uri | http://www.tuberculosisjournal.com/article/S1472-9792(12)00197-7/fulltext | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45106 | - |
dc.description.abstract | Antituberculosis drug (ATD)-induced hypersensitivity syndrome (HSS) is a serious adverse reaction to ATDs, but much remains to be determined regarding its characteristics and genetic risk factors. In this study, we have collected cases of ATD-induced HSS and their clinical features, and investigated the associations of ATD-induced HSS with human leukocyte antigen (HLA). Subjects with ATD-induced HSS and ATD-tolerant controls were recruited through analysis of a multicenter adverse drug reaction registry in Korea. HLA allele frequencies were compared between subjects with ATD-induced HSS (n = 14) and two control groups: ATD-tolerant controls (n = 166) and the general population (n = 485). The number of enrolled subjects with ATD-induced HSS (n = 14) was comparable to those of patients with HSS induced by other common drugs such as allopurinol during the recruitment period. The frequency of Cw*0401 was much higher in the cases (50.0%) compared with ATD-tolerant controls (12.7%, Pc = 0.0204, OR = 6.90) and the general population (12.8%, Pc = 0.0132, OR = 6.82). Our results suggest that ATD is an important causative agent inducing HSS with distinct clinical features. The strong association of Cw*0401 with the risk for ATD-induced HSS suggests immunological involvement in the development of this syndrome. (C) 2012 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health 21 R&D Project, the Ministry of Health and Welfare, Republic of Korea (A111218-11-PG01). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Churchill Livingstone | en_US |
dc.subject | Antituberculosis drugs | en_US |
dc.subject | Hypersensitivity syndrome | en_US |
dc.subject | Human leukocyte antigen | en_US |
dc.subject | Genetic association | en_US |
dc.title | Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 93 | - |
dc.identifier.doi | 10.1016/j.tube.2012.10.010 | - |
dc.relation.page | 270-274 | - |
dc.relation.journal | TUBERCULOSIS | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.contributor.googleauthor | Lee, Soo-Keol | - |
dc.contributor.googleauthor | Kim, Sang-Hoon | - |
dc.contributor.googleauthor | Park, Heung-Woo | - |
dc.contributor.googleauthor | Chang, Yoon-Seok | - |
dc.contributor.googleauthor | Lee, Kyung Wha | - |
dc.contributor.googleauthor | Jee, Young-Koo | - |
dc.relation.code | 2013008339 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sangheonkim | - |
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