Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen
- Title
- Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen
- Author
- 김상헌
- Keywords
- Antituberculosis drugs; Hypersensitivity syndrome; Human leukocyte antigen; Genetic association
- Issue Date
- 2013-05
- Publisher
- Churchill Livingstone
- Citation
- Tuberculosis, 2013, 93(2), P.270-274
- Abstract
- Antituberculosis drug (ATD)-induced hypersensitivity syndrome (HSS) is a serious adverse reaction to ATDs, but much remains to be determined regarding its characteristics and genetic risk factors. In this study, we have collected cases of ATD-induced HSS and their clinical features, and investigated the associations of ATD-induced HSS with human leukocyte antigen (HLA). Subjects with ATD-induced HSS and ATD-tolerant controls were recruited through analysis of a multicenter adverse drug reaction registry in Korea. HLA allele frequencies were compared between subjects with ATD-induced HSS (n = 14) and two control groups: ATD-tolerant controls (n = 166) and the general population (n = 485). The number of enrolled subjects with ATD-induced HSS (n = 14) was comparable to those of patients with HSS induced by other common drugs such as allopurinol during the recruitment period. The frequency of Cw*0401 was much higher in the cases (50.0%) compared with ATD-tolerant controls (12.7%, Pc = 0.0204, OR = 6.90) and the general population (12.8%, Pc = 0.0132, OR = 6.82). Our results suggest that ATD is an important causative agent inducing HSS with distinct clinical features. The strong association of Cw*0401 with the risk for ATD-induced HSS suggests immunological involvement in the development of this syndrome. (C) 2012 Elsevier Ltd. All rights reserved.
- URI
- http://www.tuberculosisjournal.com/article/S1472-9792(12)00197-7/fulltexthttp://hdl.handle.net/20.500.11754/45106
- ISSN
- 1472-9792
- DOI
- 10.1016/j.tube.2012.10.010
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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