Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
- Title
- Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
- Author
- 김교상
- Keywords
- Caucasian; Neostigmine; Neuromuscular blockade; Rocuronium; Sugammadex
- Issue Date
- 2013-12
- Publisher
- 대한마취통증의학회
- Citation
- Korean Journal of Anesthesiology, 2013, 65(6), P.501-507
- Abstract
- Background: Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing rapid reversal of moderate (reappearance of T2) rocuronium-induced NMB. We investigated the efficacy and safety of sugammadex versus neostigmine in Korean patients.Methods: This randomized, safety assessor-blinded trial (NCT01050543) included Korean patients undergoing general anesthesia. Rocuronium 0.6 mg/kg was given prior to intubation with maintenance doses of 0.1-0.2 mg/kg as required. Patients received sugammadex 2.0 mg/kg or neostigmine 50 μg/kg with glycopyrrolate 10 μg/kg to reverse the NMB at the reappearance of T2, after the last rocuronium dose. The primary efficacy endpoint was the time from sugammadex or neostigmine administration to recovery of the train-of-four (TOF) ratio to 0.9. The safety of these medications was also assessed.Results: Of 128 randomized patients, 118 had evaluable data (n = 59 in each group). The geometric mean (95% confidence interval) time to recovery of the TOF ratio to 0.9 was 1.8 (1.6, 2.0) minutes in the sugammadex group and 14.8 (12.4, 17.6) minutes in the neostigmine group (P < 0.0001). Sugammadex was generally well tolerated, with no evidence of residual or recurrence of NMB; four patients in the neostigmine group reported adverse events possibly indicative of inadequate NMB reversal.Conclusions: Sugammadex was well tolerated and provided rapid reversal of moderate rocuronium-induced NMB in Korean patients, with a recovery time 8.1 times faster than neostigmine. These results are consistent with those reported for Caucasian patients.
- URI
- https://ekja.org/journal/view.php?doi=10.4097/kjae.2013.65.6.501http://hdl.handle.net/20.500.11754/45024
- ISSN
- 2005-7563
- DOI
- 10.4097/kjae.2013.65.6.501
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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