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On-chip electrochemical detection of bio/chemical molecule by nanostructures fabricated in a microfluidic channel

Title
On-chip electrochemical detection of bio/chemical molecule by nanostructures fabricated in a microfluidic channel
Other Titles
chemical molecule by nanostructures fabricated in a microfluidic channel
Author
성기훈
Keywords
Microfluidic device; Electrochemical detection; Single-walled carbon nanotube; Gold nanoparticles
Issue Date
2013-02
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Sensors and actuators. B, Chemical, 177, 472 - 477
Abstract
We developed the versatile microfluidic device for on-chip electrochemical analysis in a single integrated platform. Gold nanostructures were fabricated at defined positions within microchannels by electrochemical deposition, and used as electrocatalytic materials for glucose detection and suitable sensing surfaces for ultratrace arsenic(III) detection. The continuous streaming solution in microfluidic devices allowed for enhanced mass transport to the electrodes and elimination of fouling effects, resulting in increased currents and high sensitivities. As a result, the current response showed a strong linear dependence (R2 = 0.995) in the glucose concentration range of 0.1–9 mM with an excellent sensitivity of 1.10 ± 0.07 mA cm−2 mM−1. Furthermore, in ultratrace arsenic(III) analysis, the calibration plot corresponding to peak current shows good linearity (R2 = 0.998) up to the concentration of 30 ppb and remarkable sensitivity of 4.49 ± 1.01 μA cm−2 ppb−1 in a short accumulation time of 60 s. We believe that the proposed device is a promising approach for various microfluidic applications with the extensibility of functional nanostructures and possibility of biomolecule self-assembly.
URI
https://www.sciencedirect.com/science/article/pii/S0925400512012099?via%3Dihubhttp://hdl.handle.net/20.500.11754/44860
ISSN
0925-4005
DOI
10.1016/j.snb.2012.11.030
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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