150 0

Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis

Title
Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis
Author
배상철
Keywords
Interferon regulatory factor 5; Polymorphism; Rheumatoid arthritis; Meta-analysis
Issue Date
2013-02
Publisher
Springer Science + Business Media
Citation
Molecular biology reports, Feb 2013, 40(2), P.1791-1799, 9P.
Abstract
The aim of this study was to determine whether interferon regulatory factor 5 (IRF5) polymorphisms confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. We searched the literature using the Pubmed and Embase databases and conducted meta-analyses on associations between the four IRF5 polymorphisms (rs2004640, rs729302, rs752637, and rs2280714) and RA susceptibility, using fixed and random effects models. A total of 12 comparison studies were considered in this meta-analysis, which in total involved 7,916 RA patients and 6,452 controls, and eight European, three Asian, and one Argentinean population. Meta-analysis showed an association between the minor allele of rs2004640 and RA in all subjects (odds ratio [OR]?=?0.928, 95?% confidence interval [CI]?=?0.865-0.996, P?=?0.037). After stratification by ethnicity, analysis indicated that the minor allele was significantly associated with RA in Europeans (OR?=?0.889, 95?% CI?=?0.839-0.941, P?=?5.03??10(-6)), but not in Asians (OR?=?1.057, 95?% CI?=?0.978-1.144, P?=?0.164). A direct comparison between anti-citrullinated peptide antibody-positive and -negative patients revealed no difference of the frequency of the rs2004640 minor allele (OR?=?1.047, 95?% CI?=?0.813-1.348, P?=?0.724). Meta-analysis identified a significant association between RA and the minor allele of the rs729302 polymorphism in the overall population (OR?=?0.896, 95?% CI?=?0.826-0.972, P?=?0.009) and in Asians (OR?=?0.862, 95?% CI?=?0.795-0.935, P?=?3.50??10(-5)), but not in Europeans (OR?=?0.951, 95?% CI?=?0.877-1.031, P?=?0.225). Meta-analysis showed an association between the minor allele of rs752637 and RA in Europeans (OR?=?0.858, 95?% CI?=?0.789-0.932, P?=?3.03??10(-5)), but not in Asians (OR?=?1.035, 95?% CI?=?0.918-1.168, P?=?0.572). No association was found between the rs2280714 polymorphism and RA susceptibility. This meta-analysis confirms that the IRF5 rs2004640, rs729302 and rs752637 polymorphisms are associated with RA susceptibility in different ethnic groups, especially in Europeans and Asians, but further study of this association is required in other ethnic groups.
URI
http://hdl.handle.net/20.500.11754/44532https://link.springer.com/article/10.1007/s11033-012-2233-4
ISSN
0301-4851
DOI
10.1007/s11033-012-2233-4
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE