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Effect of Regular Exercise on the Histochemical Changes of D-Galactose-Induced Oxidative Renal Injury in High-Fat Diet-Fed Rats

Title
Effect of Regular Exercise on the Histochemical Changes of D-Galactose-Induced Oxidative Renal Injury in High-Fat Diet-Fed Rats
Author
이진
Keywords
exercise; D-galactose; high-fat diet; oxidative stress; renal injury
Issue Date
2013-08
Publisher
JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY
Citation
Acta histochemica et cytochemica, Aug 2013, 46(1-6), P.111-119
Abstract
Renal lipid accumulation exhibits slowly developing chronic kidney disease and is associated with increased oxidative stress. The impact of exercise on the obese- and oxidative stress-related renal disease is not well understood. The purpose of this study was to investigate whether a high-fat diet (HFD) would accelerate D-galactose-induced aging process in rat kidney and to examine the preventive effect of regular exercise on the obese- and oxidative stress-related renal disease. Oxidative stress was induced by an administration of D-galactose (100 mg/kg intraperitoneally injected) for 9 weeks, and D-galactose-treated rats were also fed with a high-fat diet (60% kcal as fat) for 9 weeks to induce obesity. We investigated the efficacy of regular exercise in reducing renal injury by analyzing N epsilon-carboxymethyllysine (CML), 8-hydroxygluanine (8-OHdG) and apoptosis. When rats were fed with a HFD for 9 weeks in D-galactose-treated rats, an increased CML accumulation, oxidative DNA damage and renal podocyte loss were observed in renal glomerular cells and tubular epithelial cells. However, the regular exercise restored all these renal changes in HFD plus D-galactose-treated rats. Our data suggested that long-term HFD may accelerate the deposition of lipoxidation adducts and oxidative renal injury in D-galactose-treated rats. The regular exercise protects against obese- and oxidative stress-related renal injury by inhibiting this lipoxidation burden.
URI
https://www.jstage.jst.go.jp/article/ahc/46/4/46_13012/_articlehttp://hdl.handle.net/20.500.11754/44488
ISSN
0044-5991
DOI
10.1267/ahc.13012
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
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