ATP-Binding Cassette Sterol Transporters Are Differentially Expressed in Normal and Diseased Human Gallbladder
- Title
- ATP-Binding Cassette Sterol Transporters Are Differentially Expressed in Normal and Diseased Human Gallbladder
- Author
- 전대원
- Keywords
- Gallbladder epithelial cell; ABCA1; ABCG5; ABCG8
- Issue Date
- 2013-02
- Publisher
- Springer
- Citation
- Digestive diseases and sciences, 58, 2, 431 - 439
- Abstract
- Gallbladder epithelial cells (GBEC) are exposed to high cholesterol concentrations in bile, and export cholesterol via an ATP-binding cassette (ABC) transporter-mediated pathway in vitro. These findings suggest that aberrant expression and/or function of ABC sterol transporters may be associated with cholesterol-related gallbladder diseases (CAGD). In this study, we investigated the relative levels of the sterol transporters ABCA1, ABCG5, and ABCG8 in human gallbladders in CAGD, and the relationship between ABCA1 and inflammation.
- URI
- https://link.springer.com/article/10.1007/s10620-012-2481-0http://hdl.handle.net/20.500.11754/44374
- ISSN
- 0163-2116
- DOI
- 10.1007/s10620-012-2481-0
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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