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dc.contributor.author오기욱-
dc.date.accessioned2018-03-09T07:11:47Z-
dc.date.available2018-03-09T07:11:47Z-
dc.date.issued2013-04-
dc.identifier.citationNeurobiology Of Aging, April 2013, 34(4), P.1311.e7-1311.e9en_US
dc.identifier.issn0197-4580-
dc.identifier.urihttp://www.neurobiologyofaging.org/article/S0197-4580(12)00460-5/fulltext-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/44363-
dc.description.abstractThe expansion of a noncoding hexanucleotide repeat (GGGGCC) in the chromosome 9 open reading frame (C9orf72) gene has been identified as the most common cause of familial and sporadic amyotrophic lateral sclerosis (ALS) in Caucasian populations. The role of the C9orf72 repeat expansion in Korean ALS patients, however, has not been reported. We therefore investigated the frequency of the C9orf72 repeat expansion in 254 Korean patients with familial (n = 8) and sporadic (n = 246) ALS and found that none of the patients had the expansion. The number of hexanucleotide repeats ranged from 2 to 11 in the 254 ALS patients without the expansion. Our results suggest that the C9orf72 repeat expansion is not the main cause of ALS in the Korean population. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipKorean Health Technology RD Project Ministry for Health, Welfare & Family Affairs, Republic of Korea National Research Foundation of Korea (NRF) Korea government (MEST)en_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.subjectFTDen_US
dc.subjectALSen_US
dc.titleAnalysis of the C9orf72 hexanucleotide repeat expansion in Korean patients with familial and sporadic amyotrophic lateral sclerosisen_US
dc.typeArticleen_US
dc.relation.volume34-
dc.identifier.doi10.1016/j.neurobiolaging.2012.09.004-
dc.relation.page7-9-
dc.relation.journalNEUROBIOLOGY OF AGING-
dc.contributor.googleauthorJang, Ja-Hyun-
dc.contributor.googleauthorKwon, Min-Jung-
dc.contributor.googleauthorChoi, Won Jun-
dc.contributor.googleauthorOh, Ki-Wook-
dc.contributor.googleauthorKoh, Seong-Ho-
dc.contributor.googleauthorKi, Chang-Seok-
dc.contributor.googleauthorKim, Seung Hyun-
dc.relation.code2013011442-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkiwook-oh-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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