Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이항락 | - |
dc.date.accessioned | 2018-03-09T03:00:24Z | - |
dc.date.available | 2018-03-09T03:00:24Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | LIVER INTERNATIONAL, 2013, 33(4), P.535-543 | en_US |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/liv.12110/abstract;jsessionid=E9A778DF1123591C608E538515A3B8F8.f02t02 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/44010 | - |
dc.description.abstract | Background 5-hydroxytryptamine (5-HT) receptors are upregulated in activated hepatic stellate cells (HSCs), and are therefore thought to play an important role in their activation. Aim The aim of this study was to determine whether 5-HT2A receptor antagonists affect the activation or apoptosis of HSCs in vitro and/or in vivo. Methods For the in vitro experiments, the viability, apoptosis and wound healing ability of LX-2 cells were examined after treatment with various 5-HT2A receptor antagonists. Levels of HSC activation markers (procollagen type I, -SMA, TGF- and Smad 2/3) were measured. For in vivo experiments, rats were divided into three groups: (i) a control group, (ii) a disease group, in which cirrhosis was induced by thioacetamide (iii) a treatment group, in which cirrhosis was induced and a 5-HT2A receptor antagonist (sarpogrelate, 30mg/kg) was administered. Results 5-HT2A, but not 5-HT2B receptor mRNA increased with time upon HSC activation. 5-HT2A receptor antagonists (ketanserin and sarpogrelate) inhibited viability and wound healing in LX-2 cells and induced apoptosis. Expression of -SMA and procollagen type I was also inhibited. In the in vivo study, lobular inflammation was reduced in the sarpogrelate-treated group, but there was only slight and statistically insignificant attenuation of periportal fibrosis. Expression of -SMA, TGF- and Smad 2/3 was also reduced in the treatment group. Conclusions 5-HT2A receptor antagonists can reduce inflammation and the activation of HSCs in this cirrhotic model. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea 2011-0007127. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject | hepatic stellate cell | en_US |
dc.subject | fibrosis | en_US |
dc.subject | sarpogrelate | en_US |
dc.subject | 5-HT | en_US |
dc.subject | 5-HT2A receptor | en_US |
dc.title | 5-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.1111/liv.12110 | - |
dc.relation.page | 535-543 | - |
dc.relation.journal | LIVER INTERNATIONAL | - |
dc.contributor.googleauthor | Kim, Dong Chan | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Kwon, Young Il | - |
dc.contributor.googleauthor | Lee, Kang Nyeong | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.contributor.googleauthor | Lee, Oh Young | - |
dc.contributor.googleauthor | Yoon, Byung Chul | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.contributor.googleauthor | Kim, Eun Kyung | - |
dc.contributor.googleauthor | 김동찬 | - |
dc.contributor.googleauthor | 전대원 | - |
dc.contributor.googleauthor | 권영일 | - |
dc.contributor.googleauthor | 이강녕 | - |
dc.contributor.googleauthor | 이항락 | - |
dc.contributor.googleauthor | 이오영 | - |
dc.contributor.googleauthor | 윤병철 | - |
dc.contributor.googleauthor | 최호순 | - |
dc.contributor.googleauthor | 김은경 | - |
dc.relation.code | 2013011164 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | alwayshang | - |
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