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dc.contributor.author정진혁-
dc.date.accessioned2018-03-08T00:53:48Z-
dc.date.available2018-03-08T00:53:48Z-
dc.date.issued2011-08-
dc.identifier.citationJournal of Korean Medical Science, Aug 2011, 26(8), P.991-995en_US
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2011.26.8.991-
dc.description.abstractPolymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.9831). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.en_US
dc.language.isoenen_US
dc.publisherKorean ACAD Medical Scienceen_US
dc.subjectPolymorphismsen_US
dc.subjectXRCC1en_US
dc.subjectSNPen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectSusceptibilityen_US
dc.titleXRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sampleen_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume26-
dc.identifier.doi10.3346/jkms.2011.26.8.991-
dc.relation.page991-995-
dc.relation.journalJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.contributor.googleauthorRyu, Ri A.-
dc.contributor.googleauthorTae, Kyung-
dc.contributor.googleauthorMin, Hyun Jung-
dc.contributor.googleauthorJeong, Jin Hyeok-
dc.contributor.googleauthorCho, Seok Hyun-
dc.contributor.googleauthorLee, Seung Hwan-
dc.contributor.googleauthorAhn, You Hern-
dc.relation.code2011212229-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pident-


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