Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-03-06T08:53:47Z | - |
dc.date.available | 2018-03-06T08:53:47Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | ONCOLOGY REPORTS, 2012, 28(5), P.1924-1928 | en_US |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://www.spandidos-publications.com/10.3892/or.2012.2005 | - |
dc.description.abstract | Two RING fingers and DRIL1 (TRIAD1) is a proapoptotic protein that promotes p53 activation in several cancer cell lines, including MCF7, U2OS and A549 cells. In this study, we demonstrated that TRIAD1 is a novel ubiquitination target for proteasome-dependent degradation by murine double minute 2 (MDM2). TRIAD1 was found to interact with and be ubiquitinated by MDM2. RNA interference against MDM2 increased endogenous TRIAD1 protein stability. The functional study results suggested that TRIAD1 degradation by MDM2 suppresses TRIAD1-mediated cell growth. These data suggested a novel negative regulatory mechanism of TRIAD1 via MDM2 E3 ligase ubiquitination. | en_US |
dc.description.sponsorship | The authors would like to thank Dr B.A. van der Reijden (Radboud University Nijmegen Medical Centre, The Netherlands), for providing the GFP-TRIAD1 plasmids. The authors are also grateful to the members of the research group, for their support and suggestions regarding this study. The present study was financed by the 2011 Konkuk University research support program. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.subject | p53 | en_US |
dc.subject | murine double minute 2 | en_US |
dc.subject | ubiquitination | en_US |
dc.subject | two RING fingers and DRIL1 | en_US |
dc.title | TRIAD1 is negatively regulated by the MDM2 E3 ligase | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.3892/or.2012.2005 | - |
dc.relation.page | 1924-1928 | - |
dc.relation.journal | ONCOLOGY REPORTS | - |
dc.contributor.googleauthor | Bae, Seung-Hee | - |
dc.contributor.googleauthor | Jung, Jin-Hyuk | - |
dc.contributor.googleauthor | An, Sung-Kwan | - |
dc.contributor.googleauthor | Kim, Ok-Yeoun | - |
dc.contributor.googleauthor | Lee, Myoung-Joo | - |
dc.contributor.googleauthor | Lee, Jae-Ho | - |
dc.contributor.googleauthor | Park, In-Chul | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | An, In-Sook | - |
dc.relation.code | 2012207264 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
dc.identifier.researcherID | 8066538700 | - |
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