Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-03-05T08:39:50Z | - |
dc.date.available | 2018-03-05T08:39:50Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | Molecular biology reports, 39, 4, 3453 - 3460 | en_US |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s11033-011-1117-3 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/42730 | - |
dc.description.abstract | The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Meta-analysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P < 0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P < 0.001; OR = 1.748, 95% CI = 1.274-2.398, P < 0.001). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients. | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084794). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Protein tyrosine phosphatase nonreceptor 22 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.1007/s11033-011-1117-3 | - |
dc.relation.page | 3453-3460 | - |
dc.relation.journal | MOLECULAR BIOLOGY REPORTS | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Choi, Sung Jae | - |
dc.relation.code | 2012206806 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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