The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update
- Title
- The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update
- Author
- 배상철
- Keywords
- Protein tyrosine phosphatase nonreceptor 22; Polymorphism; Rheumatoid arthritis; Meta-analysis
- Issue Date
- 2012-04
- Publisher
- SPRINGER
- Citation
- Molecular biology reports, 39, 4, 3453 - 3460
- Abstract
- The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Meta-analysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P < 0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P < 0.001; OR = 1.748, 95% CI = 1.274-2.398, P < 0.001). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
- URI
- https://link.springer.com/article/10.1007/s11033-011-1117-3http://hdl.handle.net/20.500.11754/42730
- ISSN
- 0301-4851
- DOI
- 10.1007/s11033-011-1117-3
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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