148 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author공구-
dc.date.accessioned2018-03-01T06:31:03Z-
dc.date.available2018-03-01T06:31:03Z-
dc.date.issued2013-01-
dc.identifier.citationCANCER LETTERS, Vol.333, No.1 [2013], p18-31en_US
dc.identifier.issn0304-3835-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0304383512006738?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffb-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/41496-
dc.description.abstractHigh aldehyde dehydrogenase (ALDH) activity has been recognized as a marker of cancer stem cells (CSCs) in breast cancer. In this study, we examined whether inhibition of ALDH activity suppresses stem-like cell properties in a 4T1 syngeneic mouse model of breast cancer. We found that ALDH-positive 4T1 cells showed stem cell-like properties in vitro and in vivo. Blockade of ALDH activity reduced the growth of CSCs in breast cancer cell lines. Treatment of mice with the ALDH inhibitor diethylaminobenzaldehyde (DEAB) significantly suppressed 4T1 cell metastasis to the lung. Recent evidence suggests that ALDH affects the response of stem cells to hypoxia; therefore, we examined a possible link between ALDH and hypoxia signaling in breast cancer. Hypoxia-inducible factor-2 alpha (HIF-2 alpha) was highly dysregulated in ALDH-positive 4T1 cells. We observed that ALDH was highly correlated with the HIF-2 alpha expression in breast cancer cell lines and tissues. DEAB treatment of breast cancer cells reduced the expression of HIF-2 alpha in vitro. In addition, reduction of HIF-2 alpha expression suppressed in vitro self-renewal ability and in vivo tumor initiation in ALDH-positive 4T1 cells. Therefore, our findings may provide the evidence necessary for exploring a new strategy in the treatment of breast cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipWe thank Dr. Lalage M. Wakefield (National Cancer Institute, USA) for critical reading of our manuscript. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the ministry of Education, Science and Technology (2012-0003630), by a grant from the National R&D Program for Cancer Control, Ministry for Health, and Welfare, Republic of Korea (0820180).en_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDen_US
dc.subjectBreast canceren_US
dc.subjectCancer stem cellen_US
dc.subjectAldehyde dehydrogenaseen_US
dc.subjectHypoxia-inducible factor-2 alphaen_US
dc.titleHigh aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2 alphaen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume333-
dc.identifier.doi10.1016/j.canlet.2012.11.026-
dc.relation.page18-31-
dc.relation.journalCANCER LETTERS-
dc.contributor.googleauthorKim, Ran-Ju-
dc.contributor.googleauthorPark, Jeong-Ran-
dc.contributor.googleauthorRoh, Kyung-Jin-
dc.contributor.googleauthorChoi, A-Ram-
dc.contributor.googleauthorKim, Soo-Rim-
dc.contributor.googleauthorKim, Pyeung-Hyeun-
dc.contributor.googleauthorYu, Jong-Han-
dc.contributor.googleauthorLee, Jong-Won-
dc.contributor.googleauthorAhn, Sei-Hyun-
dc.contributor.googleauthorKong, Gu-
dc.relation.code2013009313-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidgkong-
dc.identifier.researcherID7006852919-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE