Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis.
- Title
- Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis.
- Author
- 윤재훈
- Keywords
- Liver fibrosis; Biological markers; Hepatic veins; Extracellular matrix; Diagnosis; TRANSIENT ELASTOGRAPHY FIBROSCAN; CHRONIC LIVER-DISEASE; SERUM MARKERS; BLOOD-TESTS; CIRRHOSIS; INFECTION; REVERSIBILITY; FIBROGENESIS; ALGORITHM; BIOPSY
- Issue Date
- 2012-09
- Publisher
- Elsevier Science B.V., Amsterdam
- Citation
- Clinical Biochemistry,Vol.45 No.13-14 [2012],p1075-1080
- Abstract
- Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 x MMP2 - 0.019 x haptoglobin and - 0.270 + 0.007 x HA - 0.018 x haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p = 0.03), MMP2 (0.72/0.63, p = 0.04), HA (0.79/0.76, p = 0.94), Apo-A1 (0.56/0.48, p = 0.73), and predictive logit-model (0.81/0.78, p = 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0009912012002160?via%3Dihubhttp://hdl.handle.net/20.500.11754/41424
- ISSN
- 0009-9120
- DOI
- 10.1016/j.clinbiochem.2012.04.031
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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