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Association between Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) and Lung Function in a Korean Population

Title
Association between Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) and Lung Function in a Korean Population
Author
고인송
Keywords
ASA-INTOLERANT ASTHMA; MYOCARDIAL-INFARCTION; GENERAL-POPULATION; LEUKOTRIENE BIOSYNTHESIS; GENETIC-VARIATION; POLYMORPHISMS; SUSCEPTIBILITY; PATHWAY; DISEASE; PHARMACOGENETICS
Issue Date
2012-08
Publisher
Blackwell Publishing Ltd
Citation
Scandinavian journal of immunology,Vol.76,No.2 [2012],p151-157
Abstract
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC4, LTD4, LTE4 and LTB4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value < 0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2012.02712.x/abstracthttp://hdl.handle.net/20.500.11754/41404
ISSN
0300-9475
DOI
10.1111/j.1365-3083.2012.02712.x
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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