Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이정한 | - |
dc.date.accessioned | 2018-03-01T01:50:53Z | - |
dc.date.available | 2018-03-01T01:50:53Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | The Journal of Urology, Sep 2012, 188(3), P.875-880 | en_US |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0022534712037159?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffb | - |
dc.description.abstract | Purpose: The pelvic tissue of women with pelvic organ prolapse is stiffer than that of controls but there are scant data on the collagen composition that corresponds to these mechanical properties. We evaluated human vaginal wall stiffness using the novel scanning haptic microscope and correlated these measurements to collagen expression in women with and without pelvic organ prolapse. In this simultaneous biomechanical and biochemical assessment we evaluated the usefulness of this measurement technology for pelvic floor disorder research and confirmed an association between mechanical properties and composition. Materials and Methods: The elastic constant (a measure of stiffness) of vaginal wall tissue was measured with the scanning haptic microscope. Protein expression of collagen types I and III of the same tissues were determined by Western blot. The Student t test was used for comparisons between groups. Results: The anterior and posterior vaginal walls of premenopausal and postmenopausal women with pelvic organ prolapse were significantly stiffer than those of controls (p < 0.05). Collagen III protein expression in the anterior vaginal wall in the control group was higher than in menopausal women. Collagen I expression was not significantly different between controls and cases. Conclusions: The scanning haptic microscope produced reliable mechanical measurements in small tissue samples without tissue destruction. Vaginal wall tissues are stiffer in women with pelvic organ prolapse than in controls. This vaginal wall stiffness was associated with lower protein expression of collagen III in the vaginal wall compared to that in asymptomatic controls. | en_US |
dc.description.sponsorship | Supported by National Institute of Aging Grant R01 AG01790 (BC), National Institute of Imaging and Bioengineering Grant 1R01 EB006170 (CC), and grants from Stanford University School of Medicine (BC) and the Fukushima Prefecture, Japan (SO). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science INC | en_US |
dc.subject | pelvic organ prolapse | en_US |
dc.subject | vagina | en_US |
dc.subject | collagen type III | en_US |
dc.subject | elasticity; microscopy | en_US |
dc.title | Biomechanical Properties and Associated Collagen Composition in Vaginal Tissue of Women with Pelvic Organ Prolapse | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 188 | - |
dc.identifier.doi | 10.1016/j.juro.2012.05.017 | - |
dc.relation.page | 875-880 | - |
dc.relation.journal | JOURNAL OF UROLOGY | - |
dc.contributor.googleauthor | Zhou, Lu | - |
dc.contributor.googleauthor | Lee, Jung Han | - |
dc.contributor.googleauthor | Wen, Yan | - |
dc.contributor.googleauthor | Constantinou, Christos | - |
dc.contributor.googleauthor | Yoshinobu, Murayama | - |
dc.contributor.googleauthor | Omata, Sadao | - |
dc.contributor.googleauthor | Chen, Bertha | - |
dc.relation.code | 2012206098 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | obgyleejh | - |
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