Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용순 | - |
dc.date.accessioned | 2018-02-28T07:46:56Z | - |
dc.date.available | 2018-02-28T07:46:56Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | The Journal of nutritional biochemistry,Vol.23,No.8 [2012],p924-928 | en_US |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0955286311001458?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41310 | - |
dc.description.abstract | Epidemiological data and clinical trials suggest that n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have preventive and therapeutic effects on depression; however, the underlying mechanism remains elusive. The present study aimed to examine the behavioral effects and antidepressant mechanism of n-3 PUFA using a forced swimming test. Eleven-week-old male Sprague Dawley rats were fed an American Institute of Nutrition-93M diet containing 0%, 0.5% or 1% EPA and DHA relative to the total energy intake in their diet for 12 weeks (n=8 per group). Total dietary intake, body weight and hippocampus weights were not significantly different among groups. The groups administered 0.5% and 1% EPA+DHA diets had significantly higher levels of n-3 PUFA in their brain phospholipids compared to those in the control group. The immobility time was significantly decreased and the climbing time was significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Plasma serotonin concentration and hippocampus c-AMP response element binding protein (CREB) expression were significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Conversely, interleukin (IL)-6 expression was significantly reduced in the 0.5% and 1% EPA+DHA groups compared with that in the 0% EPA+DHA group. However, there were no dose-dependent effects of n-3 PUFA and no significant differences in expressions of IL-1 beta, tumor necrosis factor-alpha, brain-derived neurotrophic factor or phosphorylated CREB. In conclusion, long-term intake of EPA+DHA induced antidepressant-like effects in rats and overexpression of CREB via decreased IL-6 expression. (C) 2012 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a Korea Research Foundation grant, funded by the Korean Government, 2009-0065576. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam | en_US |
dc.subject | BDNF | en_US |
dc.subject | CREB | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Depression | en_US |
dc.subject | Forced swimming test | en_US |
dc.subject | n-3 polyunsaturated fatty acids | en_US |
dc.subject | EICOSAPENTAENOIC ACID | en_US |
dc.subject | MAJOR DEPRESSION | en_US |
dc.subject | DOUBLE-BLIND | en_US |
dc.subject | FEMALE RATS | en_US |
dc.subject | HIPPOCAMPUS | en_US |
dc.subject | OMEGA-3-FATTY-ACIDS | en_US |
dc.subject | SEROTONIN | en_US |
dc.subject | NEUROTRANSMISSION | en_US |
dc.subject | PHOSPHOLIPIDS | en_US |
dc.subject | DEPRIVATION | en_US |
dc.title | N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.1016/j.jnutbio.2011.04.018 | - |
dc.relation.page | 924-928 | - |
dc.relation.journal | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.contributor.googleauthor | Park, Yongsoon | - |
dc.contributor.googleauthor | Moon, Hyoun-Jung | - |
dc.contributor.googleauthor | Kim, Seok-Hyeon | - |
dc.relation.code | 2012205543 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | yongsoon | - |
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