Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임동우 | - |
dc.date.accessioned | 2018-02-28T05:51:16Z | - |
dc.date.available | 2018-02-28T05:51:16Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | International Journal of Pharmaceutics, Sep 2012, 434(1-2), P.488-493 | en_US |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S037851731200470X?via%3Dihub | - |
dc.description.abstract | Cancer chemotherapy is often limited, since more than one molecule is usually involved with the cancer pathogenesis. A combination of therapeutic drugs would be a promising approach to overcome the complexity of tumors. In this study, a conjugate (DA3) of deoxycholic acid and low molecular weight polyethylenimine (PEI 1.8 kDa), which has a property that mimics that of cell penetrating peptides (CPPs), was used for simultaneous delivery of an anticancer drug and siRNA. When complexed with siRNA, DA3 showed significantly higher target gene silencing efficiency than PEI 25 kDa. The gene silencing efficiency of DA3 was maintained even in the presence of endocytosis inhibitors, suggesting that the polymeric carrier can mediate an endocytosis-independent macromolecular transduction similar to CPPs. The capability of forming a micelle-like core-shell structure enables the conjugates to encapsulate and dissolve paclitaxel (PTX), a water-insoluble drug. The drug-loaded cationic micelles can then interact with siRNA to form stable complexes (PTX/DA3/siRNA). The PTX/DA3/siRNA showed significantly enhanced inhibition of cancer cell growth. When administered into tumor-bearing animals, the PTX/DA3/siRNA demonstrated significant suppression of tumor growth, providing potential usefulness in clinical settings. | en_US |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2011-0019775, 2009-0088722, 2010-0027955, and 2011-0093632) and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs (A110879). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science BV | en_US |
dc.subject | Biomimetic polymer | en_US |
dc.subject | Combined delivery | en_US |
dc.subject | siRNA | en_US |
dc.subject | Anticancer drug | en_US |
dc.subject | Combination cancer therapy | en_US |
dc.title | Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 434 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.04.083 | - |
dc.relation.page | 488-493 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Jang, Yeon Lim | - |
dc.contributor.googleauthor | Yun, Ui Jeong | - |
dc.contributor.googleauthor | Lee, Min Sang | - |
dc.contributor.googleauthor | Kim, Myung Goo | - |
dc.contributor.googleauthor | Son, Sohee | - |
dc.contributor.googleauthor | Lee, Kyuri | - |
dc.contributor.googleauthor | Chae, Su Young | - |
dc.contributor.googleauthor | Jeong, Ji Hoon | - |
dc.contributor.googleauthor | Lim, Dong Woo | - |
dc.contributor.googleauthor | Kim, Hong Tae | - |
dc.contributor.googleauthor | Kim, Sun Hwa | - |
dc.contributor.googleauthor | 장연임 | - |
dc.contributor.googleauthor | 연위정 | - |
dc.contributor.googleauthor | 이민상 | - |
dc.contributor.googleauthor | 김명구 | - |
dc.contributor.googleauthor | 손소희 | - |
dc.contributor.googleauthor | 이규리 | - |
dc.contributor.googleauthor | 채수영 | - |
dc.contributor.googleauthor | 정지훈 | - |
dc.contributor.googleauthor | 임동우 | - |
dc.contributor.googleauthor | 김홍태 | - |
dc.contributor.googleauthor | 김선화 | - |
dc.relation.code | 2012204294 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | dlim | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.