Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정승준 | - |
dc.date.accessioned | 2018-02-28T05:26:48Z | - |
dc.date.available | 2018-02-28T05:26:48Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Neuron, Vol.74, No.4 [2012] p. 640?647 | en_US |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://search.proquest.com/docview/1503850892/fulltextPDF/1F58A68A6424AEEPQ/1?accountid=11283 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41194 | - |
dc.description.abstract | Neuropathic pain and allodynia may arise from sensitization of central circuits. We report a mechanism of disinhibition-based central sensitization resulting from long-term depression (LTD) of GABAergic interneurons as a consequence of TRPV1 activation in the spinal cord. Intrathecal administration of TRPV1 agonists led to mechanical allodynia that was not dependent on peripheral TRPV1 neurons. TRPV1 was functionally expressed in GABAergic spinal interneurons and activation of spinal TRPV1 resulted in LTD of excitatory inputs and a reduction of inhibitory signaling to spinothalamic tract (STT) projection neurons. Mechanical hypersensitivity after peripheral nerve injury was attenuated in TRPV1(-/-) mice but not in mice lacking TRPV1-expressing peripheral neurons. Mechanical pain was reversed by a spinally applied TRPV1 antagonist while avoiding the hyperthermic side effect of systemic treatment. Our results demonstrate that spinal TRPV1 plays a critical role as a synaptic regulator and suggest the utility of central nervous system-specific TRPV1 antagonists for treating neuropathic pain. | en_US |
dc.description.sponsorship | Thanks to Dr. Bruce P. Bean (Harvard Medical School) for helpful comments. This work was supported by grant (20110018614) from National Research Laboratory Program, grant (2011K000275) from Brain Research Center of the 21st Century Frontier Research Program, grant (2010-0015669) from Basic Research Program, and grant (2011-0030737 to S.J.K.) funded by the Ministry of Education, Science and Technology, the Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | LONG-TERM DEPRESSION | en_US |
dc.subject | DORSAL-HORN | en_US |
dc.subject | SUBSTANTIA-GELATINOSA | en_US |
dc.subject | CAPSAICIN RECEPTOR | en_US |
dc.subject | PATHOLOGICAL PAIN | en_US |
dc.subject | PRIMARY AFFERENTS | en_US |
dc.subject | EVOKED ALLODYNIA | en_US |
dc.subject | NEURONS | en_US |
dc.subject | ACTIVATION | en_US |
dc.subject | CHANNELS | en_US |
dc.title | TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 74 | - |
dc.identifier.doi | 10.1016/j.neuron.2012.02.039 | - |
dc.relation.page | 640-647 | - |
dc.relation.journal | NEURON | - |
dc.contributor.googleauthor | Kim, Yong-Ho | - |
dc.contributor.googleauthor | Back, Seung-Keun | - |
dc.contributor.googleauthor | Davies, Alexander J. | - |
dc.contributor.googleauthor | Jeong, Heejin | - |
dc.contributor.googleauthor | Jo, Hyun-Jung | - |
dc.contributor.googleauthor | Chung, Geehoon | - |
dc.contributor.googleauthor | Na, Heung-Sik | - |
dc.contributor.googleauthor | Bae, Yong-Chul | - |
dc.contributor.googleauthor | Kim, Sang-Jeong | - |
dc.contributor.googleauthor | Jung, Sung-Jun | - |
dc.relation.code | 2012207021 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | eurijj | - |
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