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dc.contributor.author구혜령-
dc.date.accessioned2018-02-28T04:46:59Z-
dc.date.available2018-02-28T04:46:59Z-
dc.date.issued2011-08-
dc.identifier.citationBREAST CANCER RESEARCH AND TREATMENT,Vol.129,No.1 [2011],p89-97en_US
dc.identifier.issn0167-6806-
dc.identifier.urihttp://link.springer.com/article/10.1007%2Fs10549-011-1627-7-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/41120-
dc.description.abstractShear wave elastography (SWE) is an emerging technique which can obtain quantitative elasticity values in breast disease. We therefore evaluated the diagnostic performance of SWE for the differentiation of breast masses compared with conventional ultrasound (US). Conventional US and SWE were performed by three experienced radiologists for 158 consecutive women who had been scheduled for US-guided core biopsy or surgical excision in 182 breast masses (89 malignancies and 93 benign; mean size, 1.76 cm). For each lesion, quantitative elasticity was measured in terms of the Young's modulus (in kilopascals, kPa) with SWE, and BI-RADS final categories were assessed with conventional US. The mean elasticity values were significantly higher in malignant masses (153.3 kPa +/- A 58.1) than in benign masses (46.1 kPa +/- A 42.9), (P < 0.0001). The average mean elasticity values of invasive ductal (157.5 +/- A 57.07) or invasive lobular (169.5 +/- A 61.06) carcinomas were higher than those of ductal carcinoma in situ (117.8 kPa +/- A 54.72). The average mean value was 49.58 +/- A 43.51 for fibroadenoma, 35.3 +/- A 31.2 for fibrocystic changes, 69.5 +/- A 63.2 for intraductal papilloma, and 149.5 +/- A 132.4 for adenosis or stromal fibrosis. The optimal cut-off value, yielding the maximal sum of sensitivity and specificity, was 80.17 kPa, and the sensitivity and specificity of SWE were 88.8% (79 of 89) and 84.9% (79 of 93). The area under the ROC curve (Az value) was 0.898 for conventional US, 0.932 for SWE, and 0.982 for combined data. In conclusion, there were significant differences in the elasticity values of benign and malignant masses as well as invasive and intraductal cancers with SWE. Our results suggest that SWE has the potential to aid in the differentiation of benign and malignant breast lesions.en_US
dc.description.sponsorshipThis study was supported by a grant from the Innovative Research Institute for Cell Therapy (A062260) and by a grant from the National R&D Program for Cancer Control (A01185), Ministry of Health & Welfare, Republic of Korea. The authors appreciated the statistical advice from the Medical Research Collaborating Center at the Seoul National University Hospital and the Seoul National University College of Medicine.en_US
dc.language.isoenen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.subjectBreast ultrasounden_US
dc.subjectShear wave elastographyen_US
dc.subjectBreast massesen_US
dc.subjectElasticity valuesen_US
dc.subjectINITIAL-EXPERIENCEen_US
dc.subjectUS ELASTOGRAPHYen_US
dc.subjectLESIONSen_US
dc.subjectMASSESen_US
dc.subjectULTRASOUNDen_US
dc.titleClinical application of shear wave elastography (SWE) in the diagnosis of benign and malignant breast diseasesen_US
dc.typeArticleen_US
dc.relation.volume129-
dc.identifier.doi10.1007/s10549-011-1627-7-
dc.relation.page89-97-
dc.relation.journalBREAST CANCER RESEARCH AND TREATMENT-
dc.contributor.googleauthorChang, Jung Min-
dc.contributor.googleauthorMoon, Woo Kyung-
dc.contributor.googleauthorCho, Nariya-
dc.contributor.googleauthorYi, Ann-
dc.contributor.googleauthorKoo, Hye Ryoung-
dc.contributor.googleauthorHan, Wonsik-
dc.contributor.googleauthorNoh, Dong-Young-
dc.contributor.googleauthorMoon, Hyeong-Gon-
dc.contributor.googleauthorKim, Seung Ja-
dc.relation.code2011201445-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhuilings-
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