The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
- Title
- The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
- Author
- 이근용
- Keywords
- adhesion; biological applications of polymers; biomaterials; hydrogels; tissue engineering
- Issue Date
- 2011-05
- Publisher
- WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
- Citation
- MACROMOLECULAR BIOSCIENCE, 11, 5, 673-679
- Abstract
- The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha 1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.
- URI
- http://onlinelibrary.wiley.com/doi/10.1002/mabi.201000479/abstract
- ISSN
- 1616-5187
- DOI
- 10.1002/mabi.201000479
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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