Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이근용 | - |
dc.date.accessioned | 2018-02-27T07:58:37Z | - |
dc.date.available | 2018-02-27T07:58:37Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | CARBOHYDRATE POLYMERS, 권: 86, 호: 3, 페이지: 1107-1112 | en_US |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0144861711004127?via%3Dihub | - |
dc.description.abstract | Hydrogels are attractive carriers for delivery of cells in tissue engineering as cell/polymer constructs can be injected into the body in a minimally invasive manner. In this study, we prepared hydrogels using only RGD-alginate and hyaluronate in the presence of primary chondrocytes without additional chemical cross-linking reagents. RGD peptides were introduced to alginate chains to increase the specific interactions with cells, and hyaluronate was used to enhance the cellular interactions and resultant gel formation. The gelation of RGD-alginate/hyaluronate hydrogels was confirmed by theological measurements. These gels were useful to regenerate cartilage tissues in vivo, which was confirmed by analysis of glycosaminoglycan secretion and chondrogenic gene expression in both qualitative and quantitative manner. This approach to controlling the gelation behavior using only cells and cell-interactive polymers could be useful for delivery of cells and therapeutics in biomedical applications. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (2010-0016065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | en_US |
dc.subject | Alginate | en_US |
dc.subject | Hyaluronate | en_US |
dc.subject | Hydrogel | en_US |
dc.subject | Injectable | en_US |
dc.subject | Drug delivery | en_US |
dc.subject | Tissue engineering | en_US |
dc.title | Facile control of RGD-alginate/hyaluronate hydrogel formation for cartilage regeneration | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 86 | - |
dc.identifier.doi | 10.1016/j.carbpol.2011.05.032 | - |
dc.relation.page | 1107-1112 | - |
dc.relation.journal | CARBOHYDRATE POLYMERS | - |
dc.contributor.googleauthor | Park, Honghyun | - |
dc.contributor.googleauthor | Lee, Kuen Yong | - |
dc.relation.code | 2011201694 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | leeky | - |
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