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dc.contributor.author이근용-
dc.date.accessioned2018-02-27T07:58:37Z-
dc.date.available2018-02-27T07:58:37Z-
dc.date.issued2011-07-
dc.identifier.citationCARBOHYDRATE POLYMERS, 권: 86, 호: 3, 페이지: 1107-1112en_US
dc.identifier.issn0144-8617-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0144861711004127?via%3Dihub-
dc.description.abstractHydrogels are attractive carriers for delivery of cells in tissue engineering as cell/polymer constructs can be injected into the body in a minimally invasive manner. In this study, we prepared hydrogels using only RGD-alginate and hyaluronate in the presence of primary chondrocytes without additional chemical cross-linking reagents. RGD peptides were introduced to alginate chains to increase the specific interactions with cells, and hyaluronate was used to enhance the cellular interactions and resultant gel formation. The gelation of RGD-alginate/hyaluronate hydrogels was confirmed by theological measurements. These gels were useful to regenerate cartilage tissues in vivo, which was confirmed by analysis of glycosaminoglycan secretion and chondrogenic gene expression in both qualitative and quantitative manner. This approach to controlling the gelation behavior using only cells and cell-interactive polymers could be useful for delivery of cells and therapeutics in biomedical applications.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (2010-0016065).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDen_US
dc.subjectAlginateen_US
dc.subjectHyaluronateen_US
dc.subjectHydrogelen_US
dc.subjectInjectableen_US
dc.subjectDrug deliveryen_US
dc.subjectTissue engineeringen_US
dc.titleFacile control of RGD-alginate/hyaluronate hydrogel formation for cartilage regenerationen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume86-
dc.identifier.doi10.1016/j.carbpol.2011.05.032-
dc.relation.page1107-1112-
dc.relation.journalCARBOHYDRATE POLYMERS-
dc.contributor.googleauthorPark, Honghyun-
dc.contributor.googleauthorLee, Kuen Yong-
dc.relation.code2011201694-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidleeky-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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