194 0

Facile control of RGD-alginate/hyaluronate hydrogel formation for cartilage regeneration

Title
Facile control of RGD-alginate/hyaluronate hydrogel formation for cartilage regeneration
Author
이근용
Keywords
Alginate; Hyaluronate; Hydrogel; Injectable; Drug delivery; Tissue engineering
Issue Date
2011-07
Publisher
ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Citation
CARBOHYDRATE POLYMERS, 권: 86, 호: 3, 페이지: 1107-1112
Abstract
Hydrogels are attractive carriers for delivery of cells in tissue engineering as cell/polymer constructs can be injected into the body in a minimally invasive manner. In this study, we prepared hydrogels using only RGD-alginate and hyaluronate in the presence of primary chondrocytes without additional chemical cross-linking reagents. RGD peptides were introduced to alginate chains to increase the specific interactions with cells, and hyaluronate was used to enhance the cellular interactions and resultant gel formation. The gelation of RGD-alginate/hyaluronate hydrogels was confirmed by theological measurements. These gels were useful to regenerate cartilage tissues in vivo, which was confirmed by analysis of glycosaminoglycan secretion and chondrogenic gene expression in both qualitative and quantitative manner. This approach to controlling the gelation behavior using only cells and cell-interactive polymers could be useful for delivery of cells and therapeutics in biomedical applications.
URI
https://www.sciencedirect.com/science/article/pii/S0144861711004127?via%3Dihub
ISSN
0144-8617
DOI
10.1016/j.carbpol.2011.05.032
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE