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dc.contributor.author배옥남-
dc.date.accessioned2018-02-26T01:51:24Z-
dc.date.available2018-02-26T01:51:24Z-
dc.date.issued2015-10-
dc.identifier.citationTOXICOLOGICAL SCIENCES, v. 147, No. 2, Page. 350-359en_US
dc.identifier.issn1096-6080-
dc.identifier.issn1096-0929-
dc.identifier.urihttps://academic.oup.com/toxsci/article/147/2/350/1620914-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/40562-
dc.description.abstractPotential risk of high-dose vitamin C consumption is often ignored. Recently, gram-dose vitamin C is being intravenously injected for the treatment of cancer, which can expose circulating blood cells to extremely high concentrations of vitamin C. As well as platelets, red blood cells (RBCs) can actively participate in thrombosis through procoagulant activation. Here, we examined the procoagulant and prothrombotic risks associated with the intravenous injection of gram-dose vitamin C. Vitamin C (0.5-5mM) increased procoagulant activity of freshly isolated human RBCs via the externalization of phosphatidylserine (PS) to outer cellular membrane and the formation of PS-bearing microvesicles. PS exposure was induced by the dysregulation of key enzymes for the maintenance of membrane phospholipid asymmetry, which was from vitamin C-induced oxidative stress, and resultant disruption of calcium and thiol homeostasis. Indeed, the intravenous injection of vitamin C (0.5-1.0 g/kg) in rats in vivo significantly increased thrombosis. Notably, the prothrombotic effects of vitamin C were more prominent in RBCs isolated from cancer patients, who are at increased risks of thrombotic events. Vitamin C-induced procoagulant and prothrombotic activation of RBCs, and increased thrombosis in vivo. RBCs from cancer patients exhibited increased sensitivity to the prothrombotic effects of vitamin C, reflecting that intravenous gram-dose vitamin C therapy needs to be carefully revisited.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF), grants funded by the Korean government (No. 2007-0056817 from the Ministry of Science, ICT and Future Planning and No. NRF-2014R1A1A2058459 from the Ministry of Education).en_US
dc.language.isoen_USen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.subjectvitamin Cen_US
dc.subjectthrombotic risken_US
dc.subjectred blood cellsen_US
dc.subjectprocoagulant activationen_US
dc.subjectcancer patienten_US
dc.subjectMICROVASCULAR ENDOTHELIAL-CELLSen_US
dc.subjectI CLINICAL-TRIALen_US
dc.subjectASCORBIC-ACIDen_US
dc.subjectPHOSPHATIDYLSERINE EXPOSUREen_US
dc.subjectVENOUS THROMBOEMBOLISMen_US
dc.subjectHYDROGEN-PEROXIDEen_US
dc.subjectPHOSPHOLIPASE-Den_US
dc.subjectIRON UPTAKEen_US
dc.subjectDISEASEen_US
dc.subjectPHARMACOKINETICSen_US
dc.titleHigh-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytesen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume147-
dc.identifier.doi10.1093/toxsci/kfv133-
dc.relation.page350-359-
dc.relation.journalTOXICOLOGICAL SCIENCES-
dc.contributor.googleauthorKim, Keunyoung-
dc.contributor.googleauthorBae, Ok-Nam-
dc.contributor.googleauthorKoh, Sung-Hee-
dc.contributor.googleauthorKang, Seojin-
dc.contributor.googleauthorLim, Kyung-Min-
dc.contributor.googleauthorNoh, Ji-Yoon-
dc.contributor.googleauthorShin, Sue-
dc.contributor.googleauthorKim, Inho-
dc.contributor.googleauthorChung, Jin-Ho-
dc.relation.code2015002654-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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