Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 공구 | - |
dc.date.accessioned | 2018-02-23T03:15:26Z | - |
dc.date.available | 2018-02-23T03:15:26Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | JOURNAL OF CELLULAR PHYSIOLOGY,226(5),1340-1352 | en_US |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/jcp.22462/abstract;jsessionid=14D9554F5A29877260A06D109DADAEC7.f04t02 | - |
dc.description.abstract | Inhibitor of differentiation-1 (Id-1) has been shown to play an essential role in cell proliferation, invasion, migration, and anti-apoptosis. However, the effect of Id-1 in mammary gland development remains unknown. Here, we generated MMTV-Id-1 transgenic mice to study the role of Id-1 in mammary gland development. In virgin mice, Id-1 overexpression led to precocious development and delayed regression of terminal end buds (TEBs) compared with wild-type mice. The number of BrdU-positive cells and the expression of Wnt signaling molecules, beta-catenin and cyclin D1, which regulate ductal extension and TEB formation in virgin, were statistically higher in Id-1 transgenic mice than in wild-type mice. Id-1 also had an effect on the formation and proliferation of lobuloalveolar structures during early and mid-pregnancy. Id-1 transgenic mice had more lobulated and prominent alveolar budding than wild-type mice and had significantly greater counts of lobuloalveolar structures in early pregnancy. The expression of BrdU, beta-catenin, and cyclin D1 was also predominantly increased in Id-1 transgenic mice. Moreover, Id-1 transgenic mice showed delayed involution. Id-1 regulated the expression levels of anti-apoptotic Bcl-2 and pro-apoptotic Bax, and resulted in delay of apoptotic peak during postlactational involution. We also found that Id-1 was able to modulate expression of the regulators of Wnt/beta-catenin signaling such as phospho-Akt, BMP2, FGF3, and RAR-beta in tubuloalveolar development of mammary glands. Taken together, our results suggest that Id-1 plays a pivotal role in mammary gland development through Wnt signaling-mediated acceleration of precocity and alveologenesis and Bcl-2 family members-mediated delay of involution. J. Cell. Physiol. 226: 1340-1352, 2011. (C) 2010 Wiley-Liss, Inc. | en_US |
dc.description.sponsorship | Contract grant sponsor: Korea Government (MEST), National Research Foundation (NRF);Contract grant numbers: 314-2007-1-E00041, 2010-0020879. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA | en_US |
dc.subject | PROSTATE-CANCER CELLS | en_US |
dc.subject | LOOP-HELIX PROTEINS | en_US |
dc.subject | NF-KAPPA-B | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | BETA-CATENIN | en_US |
dc.subject | HEPATOCELLULAR-CARCINOMA | en_US |
dc.subject | SIGNALING PATHWAY | en_US |
dc.subject | INDUCED APOPTOSIS | en_US |
dc.subject | GENE-EXPRESSION | en_US |
dc.subject | ACTIVATION | en_US |
dc.title | Constitutive Overexpression of Id-1 in Mammary Glands of Transgenic Mice Results in Precocious and Increased Formation of Terminal End Buds, Enhanced Alveologenesis, Delayed Involution | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 226 | - |
dc.identifier.doi | 10.1002/jcp.22462 | - |
dc.relation.page | 1340-1352 | - |
dc.relation.journal | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.contributor.googleauthor | Shin, Dong-Hui | - |
dc.contributor.googleauthor | Jang, Si-Hyong | - |
dc.contributor.googleauthor | Kang, Byeong-Cheol | - |
dc.contributor.googleauthor | Kim, Hyun-Jun | - |
dc.contributor.googleauthor | Oh, Seung Hyun | - |
dc.contributor.googleauthor | Kong, Gu | - |
dc.relation.code | 2011204797 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | gkong | - |
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