Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임영효 | - |
dc.date.accessioned | 2018-02-22T07:41:49Z | - |
dc.date.available | 2018-02-22T07:41:49Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | Cardiovascular Diabetology. (Cardiovascular Diabetology, 17 October 2011, 10) | en_US |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-10-92 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/39897 | - |
dc.description.abstract | Background: Diabetic cardiomyopathy (CMP) is a common and disabling disease 0000218C in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF) improves heart function in myocardial infarction, its effect on non-ischemic CMP such as diabetic CMP is unknown. In the present study, we investigated the effects of G-CSF on diabetic CMP in a rat model of type II diabetes. Methods: Twenty 7-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF: a rat model of diabetes) rats and 10 male Long-Evans Tokushima Otsuka (LETO: normal controls) rats were used. All of the LETO and 8 OLETF rats were fed on tap water while the rest were fed on sucrose-containing water. After 10 weeks, saline or recombinant human G-CSF (100 mu g/kg/day) was injected intraperitoneally for 5 days. Blood levels of glucose, total cholesterol and triglyceride, and Doppler echocardiograms for diastolic dysfunction were obtained just before and 4 weeks after the saline or G-CSF treatment. Light microscopy, electron microscopy (EM) and immunohistochemistry for transforming growth factor-beta were employed to examine myocardial histology 4 weeks after the saline or G-CSF treatment. Results: Diastolic dysfunction developed at 17 weeks (before the saline or G-CSF treatment) in the OLETF rats whether or not they were fed sucrose water, but were more severe in those fed sucrose water. Four weeks after saline or G-CSF treatment, diastolic function had recovered in the G-CSF-treated group regardless of sucrose water feeding, and perivascular and/or interstitial fibrosis in the G-CSF-treated group had decreased significantly. TGF-beta immunoreactivity in the interstitial and perivascular tissue was also reduced in the G-CSF-treated group, and EM studies revealed less severe disruption of myofilaments and mitochondrial cristae, and decreased collagen deposition. Conclusions: G-CSF can ameliorate cardiac diastolic dysfunction and morphological damage, especially fibrosis of the myocardium, in OLETF rats with diabetic CMP. | en_US |
dc.description.sponsorship | This work was supported by the grant for the Medical Research Center (2011-0028261) funded by the National Research Foundation of Korea (NRF) of the Ministry of Education, Science and Technology (MEST), Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V., | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Cardiomyopathy | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Doppler | en_US |
dc.subject | Histology | en_US |
dc.subject | Fibrosis | en_US |
dc.title | Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1186/1475-2840-10-92 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | CARDIOVASCULAR DIABETOLOGY | - |
dc.contributor.googleauthor | Lim, Young-Hyo | - |
dc.contributor.googleauthor | Joe, Jun-Ho | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | So, Byung-Im | - |
dc.contributor.googleauthor | Fang, Cheng-Hu | - |
dc.contributor.googleauthor | Shin, Jinho | - |
dc.contributor.googleauthor | (Kim, Jung-Hyun | - |
dc.contributor.googleauthor | Lim, Heon-Kil | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.contributor.googleauthor | Jang, Ki-Seok | - |
dc.relation.code | 2011217858 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | mdoim | - |
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